X3004
XAV939
≥98% (HPLC), powder, tankyrase inhibitor
别名:
3,5,7,8-四氢-2-[4-（三氟甲基）苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮
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关于此项目
经验公式（希尔记法）:
C14H11F3N2OS
化学文摘社编号:
分子量:
312.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
XAV939, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
储存温度
room temp
SMILES字符串
FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
InChI
1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChI key
KLGQSVMIPOVQAX-UHFFFAOYSA-N
应用
XAV939用于抑制
- 神经母细胞瘤细胞系中的端锚聚合酶
- 髓母细胞瘤细胞中的白喉毒素样ADP-核糖基转移酶（ARTD）
- 人诱导多能干细胞（hiPSC）中的wnt信号
生化/生理作用
XAV939是一种端锚聚合酶抑制剂（从而抑制Wnt/β-连环蛋白信号转导）
XAV939是可渗透细胞的二氢硫代吡喃嘧啶酮， 可引发抗肿瘤功能，对结肠癌、肺癌、乳腺癌和肝癌起作用。 它与端锚聚合酶中具有催化作用的多聚ADP-核糖聚合酶（PARP）结构域结合，破坏 β-联蛋白。还抑制神经母细胞瘤中的端锚聚合酶，促进肿瘤细胞凋亡。
特点和优势
该化合物是基因调控研究的推荐产品。点击这里 发现更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
其他说明
XAV939已经过Chemical Probes Portal的专业评审和推荐。有关更多信息，请访问Chemical Probes Portal网站上 XAV939探测摘要 页面。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
XAV939, a tankyrase 1 inhibitor, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wntbeta-catenin signaling pathway
Tian XH, et al.
Journal of Experimental & Clinical Cancer Research, 32(1), 100-100 (2013)
XAV939-mediated ARTD activity inhibition in human MB cell lines
Renna C, et al.
Testing, 10(4), e0124149-e0124149 (2015)
Up-regulation of FGF1519 signaling promotes hepatocellular carcinoma in the background of fatty liver
Cui G, et al.
Journal of Experimental & Clinical Cancer Research, 37(1), 136-136 (2018)
Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling
Kadari A, et al.
Stem Cell Reviews and Reports, 11(4), 560-569 (2015)
Nicolas C Rivron et al.
Nature, 557(7703), 106-111 (2018-05-04)
The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic tissues, including the placenta. It consists of a spherical thin-walled layer, known as the trophectoderm, that surrounds a fluid-filled cavity sheltering the embryonic cells 1 . From mouse blastocysts
商品
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