X3004
XAV939
≥98% (HPLC), powder, tankyrase inhibitor
别名:
3,5,7,8-四氢-2-[4-（三氟甲基）苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮
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关于此项目
经验公式（希尔记法）:
C14H11F3N2OS
化学文摘社编号:
分子量:
312.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
XAV939, ≥98% (HPLC)
SMILES string
FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
InChI
1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChI key
KLGQSVMIPOVQAX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
room temp
Quality Level
Application
XAV939用于抑制
- 神经母细胞瘤细胞系中的端锚聚合酶
- 髓母细胞瘤细胞中的白喉毒素样ADP-核糖基转移酶（ARTD）
- 人诱导多能干细胞（hiPSC）中的wnt信号
Biochem/physiol Actions
XAV939是一种端锚聚合酶抑制剂（从而抑制Wnt/β-连环蛋白信号转导）
XAV939是可渗透细胞的二氢硫代吡喃嘧啶酮， 可引发抗肿瘤功能，对结肠癌、肺癌、乳腺癌和肝癌起作用。 它与端锚聚合酶中具有催化作用的多聚ADP-核糖聚合酶（PARP）结构域结合，破坏 β-联蛋白。还抑制神经母细胞瘤中的端锚聚合酶，促进肿瘤细胞凋亡。
Features and Benefits
该化合物是基因调控研究的推荐产品。点击这里 发现更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
Other Notes
XAV939已经过Chemical Probes Portal的专业评审和推荐。有关更多信息，请访问Chemical Probes Portal网站上 XAV939探测摘要 页面。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
XAV939, a tankyrase 1 inhibitor, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wntbeta-catenin signaling pathway
Tian XH, et al.
Journal of Experimental & Clinical Cancer Research, 32(1), 100-100 (2013)
Tankyrase inhibitors attenuate WNTbeta-catenin signaling and inhibit growth of hepatocellular carcinoma cells
Ma L, et al.
Testing, 6(28), 25390-25390 (2015)
XAV939-mediated ARTD activity inhibition in human MB cell lines
Renna C, et al.
Testing, 10(4), e0124149-e0124149 (2015)
Up-regulation of FGF1519 signaling promotes hepatocellular carcinoma in the background of fatty liver
Cui G, et al.
Journal of Experimental & Clinical Cancer Research, 37(1), 136-136 (2018)
Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling
Kadari A, et al.
Stem Cell Reviews and Reports, 11(4), 560-569 (2015)
商品
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