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Merck
CN

X2254

Sigma-Aldrich

XE-991

≥98% (HPLC)

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别名:
10,10-双(4-萘甲基)-9(10H)-蒽酮
经验公式(希尔记法):
C26H20N2O
分子量:
376.45
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

颜色

white to beige

溶解性

DMSO: >20 mg/mL

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

2-8°C

SMILES字符串

O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15

InChI

1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2

InChI key

KHJFBUUFMUBONL-UHFFFAOYSA-N

应用

XE-991已被利用KCNQ(Kv7.2 / 7.3)抑制剂,以检查M电流抑制是否影响催产素受体(TGOT)介导的去极化。也曾作为 KCNQ 抑制剂用于研究河豚毒素(TTX)存在时小鼠胆碱能中间神经元(ChIs)膜电位超射/欠射的离子机制。

生化/生理作用

XE-991 是一种 KCNQ 通道阻滞剂;它比利诺哌啶(目录号L-134)更有效。

特点和优势

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面, 请单击此处
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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