X2254
XE-991
≥98% (HPLC), powder, KCNQ channel blocker
别名:
10,10-双（4-萘甲基）-9（10H）-蒽酮
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关于此项目
经验公式（希尔记法）:
C26H20N2O
化学文摘社编号:
分子量:
376.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
XE-991, ≥98% (HPLC)
SMILES string
O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
InChI key
KHJFBUUFMUBONL-UHFFFAOYSA-N
InChI
1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
assay
≥98% (HPLC)
color
white to beige
solubility
DMSO: >20 mg/mL
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.
2-8°C
Quality Level
Application
XE-991已被利用KCNQ（Kv7.2 / 7.3）抑制剂，以检查M电流抑制是否影响催产素受体（TGOT）介导的去极化。也曾作为 KCNQ 抑制剂用于研究河豚毒素（TTX）存在时小鼠胆碱能中间神经元（ChIs）膜电位超射/欠射的离子机制。
Biochem/physiol Actions
XE-991 是一种 KCNQ 通道阻滞剂。
XE-991 是一种 KCNQ 通道阻滞剂；它比利诺哌啶（目录号L-134）更有效。
Features and Benefits
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Neuropharmacology, 161, 107568-107568 (2019-03-20)
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Yusuf Olgar et al.
Journal of cellular physiology, 237(2), 1353-1371 (2021-10-12)
Insufficient-heart function is associated with myocardial insulin resistance in the elderly, particularly associated with long-QT, in a dependency on dysfunctional KCNQ1/KCNE1-channels. So, we aimed to examine the contribution of alterations in KCNQ1/KCNE1-current (IKs ) to the aging-related remodeling of the heart
Eider Nuñez et al.
eLife, 12 (2023-02-22)
Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation of the channels. Recent structural insights reveal potential
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Zhang Y, et al.
Neuron, 98(5), 918-925 (2018)
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