生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
浓度
~1 mg/mL
技术
indirect immunofluorescence: 2-4 μg/mL using HEK-293T cells expressing recombinant XPG fusion protein, fixed with paraformaldehyde-Triton
western blot: 1-2 μg/mL using whole cell lysates of COS7 cells expressing recombinant XPG fusion protein
一般描述
Anti-XPG (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue. Xeroderma pigmentosum group G (XPG) is a DNA repair gene, that is mapped to human chromosome13q33. It is a member of the FEN-1 family of structure-specific nucleases and contains two highly conserved nuclease motifs known as the N and I regions separated by a large insertion. This gene spans around 69kb in length and has15 exons. It is highly polymorphic.
免疫原
synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue.
应用
Anti-XPG (C-terminal) antibody produced in rabbit has been used in:
- staining cells for xeroderma pigmentosum group G (XPG) detection
- immunoblotting
- immunofluorescence
生化/生理作用
Xeroderma pigmentosum group G (XPG) helps to maintain genomic stability. It also participates in RNA transcription by interacting with TFIIH, RNA polymerase II and Gadd45a. XPG also participates in nucleotide excision repair (NER) pathway. Mutations in the XPG gene cause the Cockayne syndrome which is characterized by severe growth defects, mental retardation and cachexia.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity
Hohl M, et al.
Nucleic Acids Research, 35(9), 3053-3063 (2007)
Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer
Hyytinen ER, et al.
Prostate, 41(3), 190-195 (1999)
XPG rs873601 G> A contributes to uterine leiomyoma susceptibility in a Southern Chinese population
Liu Z, et al.
Bioscience Reports, 38(5), BSR20181116-BSR20181116 (2018)
Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method
Shiomi N, et al.
Molecular and Cellular Biology, 24(9), 3712-3719 (2004)
Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
Seoane M, et al.
Oncogene, 38(19), 3616-3616 (2019)
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