生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4H4, monoclonal
形式
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG1κ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RHOT1(55288)
一般描述
Ras同源物家族成员T1（RHOT1）由位于人染色体 17q11.2的基因编码。RhoT1是线粒体Rho GTPase家族成员。
免疫原
带GST标签的RHOT1（NP_060777，483 a.a. ~ 580 a.a）部分重组蛋白。GST标签的分子量为26 KDa。
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
序列
TEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP
生化/生理作用
Ras同源物家族成员T1（RHOT1）在线粒体稳态和细胞凋亡的控制中起着至关重要的作用。RHOT1 可作为胰腺癌（PC）的肿瘤抑制基因，它被认为是总体生存率的潜在预后生物标志物，也有望成为PC治疗靶点。RHOT1表达的下降可能导致淋巴结转移（LNM）和较短的生存期。RHOT1在线粒体运输、淋巴细胞迁移和极性中发挥重要作用。
外形
溶于pH7.4的磷酸盐缓冲盐水中的溶液
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
Hua Jiang et al.
PloS one, 7(7), e42234-e42234 (2012-08-04)
Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to
Pei-I Tsai et al.
Molecular biology of the cell, 28(24), 3471-3479 (2017-09-15)
MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing
Renu Bajaj et al.
Molecular cytogenetics, 4, 3-3 (2011-01-22)
To evaluate the clinical validity of genome-wide oligonucleotide array comparative genomic hybridization (aCGH) for detecting somatic abnormalities, we have applied this genomic analysis to 30 cases (13 MDS and 17 AML) with clonal chromosomal abnormalities detected in more than 50%
Clara Berenguer-Escuder et al.
Journal of clinical medicine, 8(12) (2020-01-01)
Although most cases of Parkinson´s disease (PD) are idiopathic with unknown cause, an increasing number of genes and genetic risk factors have been discovered that play a role in PD pathogenesis. Many of the PD-associated proteins are involved in mitochondrial
Jinshan Qin et al.
Nature communications, 11(1), 4471-4471 (2020-09-10)
A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging
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