WH0009804M1
TOMM20单克隆抗体 小鼠抗
clone 4F3, purified immunoglobulin, buffered aqueous solution
别名:
抗KIAA0016, 抗MAS20, 抗MGC117367, 抗MOM19, 抗TOM20, 抗线粒体外膜20同源物转位酶（酵母）
产品名称
TOMM20单克隆抗体 小鼠抗, clone 4F3, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4F3, monoclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TOMM20(9804)
Biochem/physiol Actions
线粒体外膜转位酶 20（TOMM20）是多成分动态复合物（multiple component- dynamic complex）的亚基，该复合物在输送某些胞质蛋白进入或通过线粒体外膜中起关键作用。它可用作含有以线粒体为靶标的N末端可裂解前序列的前体蛋白受体。核呼吸因子 2（NRF-2）在人TOMM20基因转录的调节中起至关重要的作用。TOMM20 具有成为胃癌的预后生物标志物和治疗靶点的潜力。TOMM20 可作为内耳中线粒体蛋白输入的标志物，TOMM20表达的减少与梅尼埃病有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
线粒体外膜转位酶 20（TOMM20）是一种20kb的基因，含有五个外显子和四个内含子，位于人类染色体 1q42.3。该基因编码TOMM20 受体，该受体是线粒体外膜转位酶的亚基。TOMM20 受体含有一个膜锚定结构域（membrane anchor domain）和一个胞质结构域（cytosolic domain），主要在人耳蜗中表达。
Immunogen
TOMM20（AAH66335, 1 a.a. ~ 145 a.a）全长重组蛋白，带GST标签。GST标签的分子量为26 KDa。
序列
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
序列
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
Physical form
溶于磷酸盐缓冲盐水，pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Z Zhao et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(10), 1361-1368 (2014-05-14)
To explore metabolic symbiosis in gastric cancer and its relationship with cancer prognosis. Immunohistochemistry was used to detect MCT4 and TOMM20 expression in 113 gastric cancer patient specimens. The correlations of MCT4 and TOMM20 expression with gastric cancer clinicopathological features
Paola Agüi-Gonzalez et al.
Nanomaterials (Basel, Switzerland), 11(7) (2021-08-08)
Nanoscale imaging with the ability to identify cellular organelles and protein complexes has been a highly challenging subject in the secondary ion mass spectrometry (SIMS) of biological samples. This is because only a few isotopic tags can be used successfully
Sinem K Saka et al.
Nature communications, 5, 3664-3664 (2014-04-11)
The isotopic composition of different materials can be imaged by secondary ion mass spectrometry. In biology, this method is mainly used to study cellular metabolism and turnover, by pulsing the cells with marker molecules such as amino acids labelled with
Motohisa Tada et al.
Cancer science, 101(5), 1261-1269 (2010-03-25)
We sought to identify genomic changes that could be useful for clinical application, focusing on chromosomal instability and using a high-density single nucleotide polymorphism (SNP) array. We analyzed 34 gastric cancer cell lines for areas of DNA that exhibited copy
José R Blesa et al.
Gene, 391(1-2), 198-208 (2007-02-16)
TOMM20 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of precursor proteins with N-terminal cleavable presequences targeted to the mitochondria. Nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) play an
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