WH0003146M8
单克隆抗-HMGB1 小鼠抗
clone 2F6, purified immunoglobulin, buffered aqueous solution
别名:
抗-DKFZp686A04236, 抗-HMG1, 抗-HMG3, 抗-SBP1, 抗-高迁移率族蛋白b1
产品名称
单克隆抗-HMGB1 小鼠抗, clone 2F6, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2F6, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HMGB1(3146)
Application
在小鼠单克隆抗HMGB1抗体可用于使用荧光显微镜和蛋白质印迹检测胰腺导管腺癌（PDAC）细胞系中的HMGB1。
Biochem/physiol Actions
高迁移率族蛋白1（HMGB1）的功能是稳定核小体，并调节基因转录。HMGB1中核定位信号的磷酸化调节其在细胞质和细胞核之间的转运。它通过引发伴侣功能来帮助核小体重塑。炎症触发HMGB1的高表达，其抑制可用于治疗难治性肺炎支原体肺炎（RMPP）。HMGB1水平升高存在于心血管疾病中。HMGB1调节缺氧后再灌注后人肝细胞中的自噬。高HMGB1表达见于腺癌（AC）、胆囊癌和鳞状细胞/腺鳞癌（SC/ASC）。HMGB1的多态性存在于口腔鳞状细胞癌（OSCC）中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
高迁移率族蛋白1（HMGB1）是一种DNA结合蛋白，由C端带负电荷的氨基酸和两个称为BOX A和B的DNA结合基序组成。HMGB1定位于人染色体13q12.3。坏死细胞和神经炎表达HMGB1。激活后的单核细胞和巨噬细胞释放HMGB1。
Immunogen
HMGB1（NP_002119, 1 a.a.~ 90 a.a）带有GST标签的部分重组蛋白。仅GST标签的MW为26 KDa。
序列
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
序列
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
Physical form
溶于pH7.4的磷酸盐缓冲盐水中的溶液
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
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Cancer research, 72(16), 3967-3976 (2012-06-16)
Although it has been shown that chemoradiotherapy may induce immunogenic cell death, which could trigger T-cell immunity mediated by high-mobility group box 1 protein (HMGB1) and calreticulin, there is still limited information to support this theory directly in a clinical
The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding
Bonaldi T, et al.
The Embo Journal, 21(24), 6865-6873 (2002)
Inhibition of HIF-1alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
Zhao T, et al.
Oncotarget, 6(4), 2250-2250 (2015)
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Cohen Jr MM
American Journal of Medical Genetics. Part A, 161(11), 2750-2755 (2013)
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