Monoclonal Anti-CAMK2D antibody produced in mouse

The gene encoding calcium/calmodulin dependent protein kinase IIδ (CAMK2D) is localized on human chromosome 4q26. The encoded protein is a member of serine/threonine protein kinase family and the Ca²⁺/calmodulin-dependent protein kinase subfamily.

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: α, β, γ, and δ. The product of this gene is a δ chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns

CAMK2D (AAH32784, 301 a.a. ~ 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPI

As a subunit of the calcium/calmodulin dependent protein kinase II complex, calcium/calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca²⁺ handling proteins. It also regulates the phosphorylation and acetylation of histones. CAMK2D has been shown to be overexpressed in the myocardium of diabetic patients.

Solution in phosphate buffered saline, pH 7.4

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