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安全信息

W3641

Sigma-Aldrich

Anti-WSTF (N-Terminal) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BAZ1B, Anti-Bromdomain Adjacent to Zn Finger Domain 1B, Anti-Williams Syndrome Transcription Factor, Anti-Williams-Beuren Syndrome Chromosome Region 9

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 175 kDa

种属反应性

human

技术

immunoprecipitation (IP): 5-10 μg using from lysates of HEK293-T cells
western blot: 0.5-1 μg/mL using extracts of MCF-7 breast cancer cell line

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... BAZ1B(9031)
mouse ... Baz1b(22385)
rat ... Baz1b(368002)

一般描述

The gene encoding Williams syndrome transcription factor (WSTF)/bromodomain adjacent to zinc finger domain 1B (BAZ1B), contains 20 exons extended over a length of 80kb on genomic DNA. The gene is localized on human chromosome 7q11.23. The encoded protein is composed of 1425 amino acids and is widely expressed in both adult and fetal tissues. WSTF contains one PHD-type zinc finger motif and a bromo domain.

免疫原

synthetic peptide corresponding to amino acids 2-20 of human WSTF, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, mouse, and rat.

应用

Anti-WSTF (N-Terminal) antibody produced in rabbit has been used in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

生化/生理作用

Williams syndrome transcription factor (WSTF) acts as a key component of WICH (WSTF-ISWI chromatin remodeling complex) and the WINAC (WSTF including the nucleosome assembly complex). WICH and WINAC complexes plays a vital role in replication of heterochromatin and vitamin D-mediated transcription and replication, respectively. In addition, WSTF is also involved in neurodevelopment. Hemizygous deletion of the gene leads to a neurodevelopmental disorder, Williams syndrome (WS).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

A Novel Human Gene,WSTF,Is Deleted in Williams Syndrome
Lu X
Genomics, 54, 241-249 (1998)
The WSTF-SNF2h Chromatin Remodeling Complex Interacts with Several Nuclear Proteins in Transcription
Cavellan E
The Journal of Biological Chemistry, 281, 16264-16271 (2006)
Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways
Lalli MA
Human Molecular Genetics, 25, 1294-1306 (2016)
Aleksandra Grochowska et al.
American journal of cancer research, 12(10), 4751-4763 (2022-11-17)
Bromodomain Adjacent to Zinc Finger Domain 1B (BAZ1B) is involved in multiple nuclear processes, and its role in tumorigenesis is emerging. However, the function of BAZ1B in colorectal cancer (CRC) remains largely unexplored. High-density tissue microarrays comprising 100 pairs of
Stephanie A Morris et al.
Nature structural & molecular biology, 21(1), 73-81 (2013-12-10)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4 and Snf2h. The

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