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安全信息

W3516

Sigma-Aldrich

Anti-WSTF (C-Terminal) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BAZ1B, Anti-Bromdomain Adjacent to Zn Finger Domain 1B, Anti-Williams Syndrome Transcription Factor, Anti-Williams-Beuren Syndrome Chromosome Region 9

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About This Item

MDL编号:
MFCD08705535
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 175 kDa

种属反应性

human, mouse

技术

immunoprecipitation (IP): 5-10 μg using from lysates of HEK293-T cells
indirect immunofluorescence: 10-20 μg/mL using paraformaldehyde-fixed NIH3T3 cells
microarray: suitable
western blot: 0.5-1 μg/mL using extracts of MCF-7 breast cancer cell line

UniProt登记号

Q9UIG0

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... BAZ1B(9031)
mouse ... Baz1b(22385)
rat ... Baz1b(368002)

一般描述

Williams syndrome transcription factor (WSTF) belongs to the WAL/BAZ/WAC protein family, encoded by the bromodomain adjacent to zinc finger domain 1B (BAZ1B) gene. It is a non-secretory protein, which consists of a C-terminal bromodomain adjacent to a PHD (plant homeodomain) finger.

免疫原

synthetic peptide corresponding to amino acids 1467-1483 of human WSTF, conjugated to KLH via an N-terminal added cysteine residue. The corresponding rat and mouse sequence differ from the immunizing sequence by three amino acids.

应用

Anti-WSTF (C-Terminal) antibody produced in rabbit has been used in western blotting and immunofluorescence.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

Williams syndrome transcription factor (WSTF) is implicated in transcription, replication, chromatin remodeling and DNA damage response. It acts as a tyrosine protein kinase. Mutations in this gene are associated with Williams-Beuren syndrome. WSTF might function as an activator of gene expression of cytochrome P450 family 21 subfamily A member 2 (CYP21A2) and CYP19A1.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000213594
0000213594
21160633
21160633
086M4818V

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Differences in embryo quality are associated with differences in oocyte composition: a proteomic study in inbred mice
Pfeiffer MJ, et al.
Proteomics, 15(4), 675-687 (2015)
Martin J Pfeiffer et al.
Proteomics, 15(4), 675-687 (2014-11-05)
Current models of early mouse development assign roles to stochastic processes and epigenetic regulation, which are considered to be as influential as the genetic differences that exist between strains of the species Mus musculus. The aim of this study was
KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway
Liu Y, et al.
Testing, 7(33), 53153-53153 (2016)
WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways
Meng J, et al.
Cellular Signalling, 28(11), 1673-1682 (2016)
Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1alpha, 25-dihydroxyvitamin D3
Lundqvist J, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 177, 171-178 (2018)
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