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检测方案
≥98% (HPLC)
质量水平
形式
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN(C)CC(O)Cn1c2ccc(Br)cc2c3cc(Br)ccc13
InChI
1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
InChI key
XUBJEDZHBUPBKL-UHFFFAOYSA-N
一般描述
Wiskostatin是一种二溴化咔唑。其N-烷基化侧链包含一个手性羟基和一个末端叔胺。
应用
Wiskostatin已被用于：
- 在人骨肉瘤 U2OS 细胞和小鼠尾成纤维细胞系中作为 Wiskott-Aldrich 综合征蛋白 (WASP) 的小分子抑制剂
- 作为培养神经元 以及在表达 HA-Parkin 的人胚胎肾 (HEK293) 细胞中的神经 (N)-WASP抑制剂
- 作为背根神经节 (DRG) 细胞中的神经 (N)-WASP 抑制剂，研究血管内皮生长因子 (VEGF) 对肌动蛋白相关蛋白 2/3 复合物 (Arp 2/3) 的影响
生化/生理作用
Wiskostatin 是 N-WASP 的选择性抑制剂，N-WASP 是 Wiskott-Aldrich 综合征蛋白 (WASP) 家族中广泛表达的成员，调控肌动蛋白聚合。维司他丁抑制肌动蛋白依赖性细胞功能，包括迁移、跨膜转运和吞噬作用。
Wiskostatin可介导胞质分裂的抑制作用。它可与 WASP 相互作用，尤其是与调节鸟苷-5′-三磷酸 (GTP) 酶结合域 (GBD)发生结合。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 4
WGK
WGK 3
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