W1895
WAY-100135
≥98% (HPLC)
别名:
3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride;, N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride
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所有图片(1)
About This Item
经验公式（希尔记法）:
C24H33N3O2 · 2HCl
CAS号:
分子量:
468.46
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
H2O: ≥10 mg/mL
创始人
Wyeth
储存温度
2-8°C
SMILES字符串
Cl.Cl.COc1ccccc1N2CCN(CC2)CC(C(=O)NC(C)(C)C)c3ccccc3
InChI
1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H
InChI key
VJGZNBYDSDEOED-UHFFFAOYSA-N
生化/生理作用
WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).
WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B,1C,2, α1, α2 and D2 receptors (IC50 > 1000 nM).
特点和优势
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kangjian Xiang et al.
Current neurovascular research, 13(4), 321-328 (2016-10-26)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT
Daniel Sobrido-Cameán et al.
Disease models & mechanisms, 12(2) (2019-02-03)
Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin
Lei Han et al.
The Journal of physiology, 599(1), 253-267 (2020-10-03)
Chemogenetic activation of medial vestibular nucleus-projecting 5-HT neurons resulted in deficits in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. The 5-HT1A receptor mediates the vestibular-related behavioural effects of 5-HT in the vestibular nucleus. 5-HT1A receptor activation attenuated
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