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About This Item
经验公式（希尔记法）:
C14H18Cl3N5O2
CAS号:
分子量:
394.68
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: 0.2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CC1(C)N=C(N)N=C(N)N1OCCCOc2cc(Cl)c(Cl)cc2Cl
InChI
1S/C14H18Cl3N5O2/c1-14(2)21-12(18)20-13(19)22(14)24-5-3-4-23-11-7-9(16)8(15)6-10(11)17/h6-7H,3-5H2,1-2H3,(H4,18,19,20,21)
InChI key
MJZJYWCQPMNPRM-UHFFFAOYSA-N
生化/生理作用
WR99210 是恶性疟原虫二氢叶酸还原酶 (DHFR) 的强效抑制剂，DHFR 是主要的疟疾药物靶点。它对野生型、双突变型和四突变型二氢叶酸还原酶具有亚纳摩尔级的效价。
二氢叶酸还原酶 (DHFR) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D A Fidock et al.
Molecular pharmacology, 54(6), 1140-1147 (1998-12-18)
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the spread of drug-resistant strains of the malaria parasite Plasmodium falciparum. Here we describe a transformation system, involving WR99210 selection of parasites transformed with either
Annemarie v d Wel et al.
Molecular and biochemical parasitology, 134(1), 97-104 (2004-01-30)
Plasmodium knowlesi provides a highly versatile transfection system for malaria, since it enables rapid genetic modification of the parasite both in vivo as well as in vitro. However, it is not possible to perform multiple genetic manipulations within one parasite
Alyson Auliff et al.
The American journal of tropical medicine and hygiene, 75(4), 617-621 (2006-10-14)
The increasing use of sulfadoxine-pyrimethamine (SP) for the treatment of chloroquine-resistant Plasmodium falciparum has resulted in increased reports of SP resistance of P. falciparum worldwide. Selection of SP-resistant Plasmodium vivax in areas where P. falciparum and P. vivax co-exist is
Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination.
Alexander G Maier et al.
Molecular and biochemical parasitology, 150(1), 118-121 (2006-08-12)
E G Hankins et al.
Molecular and biochemical parasitology, 117(1), 91-102 (2001-09-12)
We have expressed dhfr alleles of Plasmodium falciparum in the budding yeast, Saccharomyces cerevisiae, and used this yeast model to identify single amino acid substitutions that confer high level pyrimethamine resistance on the background of the triple mutant dhfr (I51+R59+N108).
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