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Merck
CN

W1020

Sigma-Aldrich

W146 水合物

≥98% (HPLC)

别名:

ML056, R-3-氨基-4-(3-己基苯氨基)-4-氧丁基膦酸水合物, [(3R)-3-氨基-4-[(3-己基苯基)氨基]-4-氧丁基]-膦酸

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About This Item

经验公式(希尔记法):
C16H27N2O4P · xH2O
分子量:
342.37 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

off-white

溶解性

methanol: soluble (with 0.1% TFA)

创始人

Novartis

储存温度

2-8°C

SMILES字符串

O.CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1

InChI

1S/C16H27N2O4P.H2O/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);1H2/t15-;/m1./s1

InChI key

DQKSZHVSROOTFY-XFULWGLBSA-N

一般描述

W146 水合物作为正构拮抗剂发挥作用。与小鼠血液淋巴细胞减少和肺水肿有关。

应用

W146 水合物已用于评估小鼠的血管通透性。

生化/生理作用

有效的 S1P (1) 竞争性拮抗剂;Ki = 10-77 nM。

特点和优势

该化合物在受体分类和信号转导手册中 溶血磷脂受体 页面中进行了详细介绍。想要浏览手册的其他页面, 请单击此处
该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

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分析证书(COA)

Lot/Batch Number

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访问文档库

Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Tarrason G, et al.
International Immunopharmacology, 11(11), 1773-1779 (2011)
María V Simón et al.
Investigative ophthalmology & visual science, 56(10), 5808-5815 (2015-09-02)
Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular mediator and
Shahzad Nawaz Syed et al.
International journal of molecular sciences, 21(13) (2020-07-08)
Recent studies suggested an important contribution of sphingosine-1-phospate (S1P) signaling via its specific receptors (S1PRs) in the production of pro-inflammatory mediators such as Interleukin (IL)-1β in cancer and inflammation. In an inflammation-driven cancer setting, we previously reported that myeloid S1PR1
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen PM, et al.
Faseb Journal, 30(6), 2351-2359 (2016)

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