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About This Item
经验公式（希尔记法）:
C16H12O5 · xH2O
CAS号:
分子量:
284.26 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
O.COc1c(O)cc(O)c2C(=O)C=C(Oc12)c3ccccc3
InChI
1S/C16H12O5.H2O/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9;/h2-8,17,19H,1H3;1H2
InChI key
XLCSETHCROERAU-UHFFFAOYSA-N
一般描述
汉黄芩素是从黄芩根提取的一种黄酮类化合物。
应用
汉黄芩素水合物可用于增强奥沙利铂对胃癌细胞和斑马鱼移植瘤模型的细胞毒性以及检测其对成熟3T3-L1脂肪细胞脂联素表达和分泌的影响。
生化/生理作用
Wogonin 是一种抗炎药和 COX-2 抑制剂，可抑制 iNOS 和 COX-2 的诱导。
Wogonin 是一种抗炎药和 COX-2 抑制剂，可抑制 iNOS 和 COX-2 的诱导。Wogonin 抑制 COX-2（IC50 = 46 μM）而不影响 COX-1。Wogonin 抑制 iNOS 诱导，从而抑制激活诱导的 C6 胶质细胞死亡。具体而言，Wogonin 抑制 NF-κB 介导的 iNOS 诱导。
汉黄芩素可与化疗药物奥沙利铂协同使用，增强其对胃癌细胞的诱导凋亡和抗肿瘤作用。它还能提高氟尿嘧啶和紫杉醇的疗效。汉黄芩素的抗氧化功能可用于治疗神经退行性疾病和炎症。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Xiuming Song et al.
Toxicology and applied pharmacology, 271(2), 144-155 (2013-05-28)
Wogonin, a plant-derived flavone, has been shown recently to have antitumor effects. However, the mechanisms that wogonin inhibits tumor angiogenesis are not well known. In this study, we investigated the effects of wogonin on expression of hypoxia-inducible factor-1α (HIF-1α) and
Yoshiyuki Kimura et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(3-4), 328-336 (2012-12-12)
Tumor growth and metastasis are associated with angiogenesis and lymphangiogenesis through the production of vascular endothelial growth factor (VEGF) or VEGF-C in tumors, and the phosphorylation of VEGF receptor (VEGFR)-2 or VEGFR-3 in vascular endothelial cells or lymphatic endothelial cells
Meng Zhang et al.
Life sciences, 92(1), 55-62 (2012-11-13)
Wogonin is one of the major constituents derived from Scutellaria Baicalensis, which has been reported to inhibit cell growth and/or induce apoptosis in various cancer cell lines. We aim to investigate the anticancer effects and associated mechanisms of wogonin on
Zhi-Pan Hong et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 39, 168-175 (2018-02-13)
Gastric cancer remains one of the leading cause of death in the world. Drug combinations are potential approaches to provide more efficient treatments that minimize side effects. We investigated the pharmacological effects of the combination of wogonin with oxaliplatin on
Fei Wang et al.
Toxicology, 305, 10-19 (2012-12-19)
Wogonin, a naturally occurring monoflavonoid extracted from the root of Scutellaria baicalensis Georgi, has been reported for its anti-oxidant activity. However, it is still unclear whether wogonin can inhibit oxidant-induced vascular permeability. In this study, we evaluated the effects of
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