生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
CD-29, monoclonal
包含
15 mM sodium azide
技术
indirect ELISA: 1:5,000
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
一般描述
单克隆抗维生素B12抗体与人血浆和血清中的维生素B12以及维生素B12-KLH和维生素B12-BSA偶联物反应。
维生素B12或称钴胺素是一种水溶性维生素。它是所有维生素中最大、最复杂的维生素。维生素B12天然存在于动物食品、肉、奶、蛋、鱼和贝类中。
应用
单克隆抗维生素（B12）抗体已被用于酶联免疫吸附测定（ELISA）。
小鼠抗维生素B12单克隆抗体还可用于免疫细胞化学。
生化/生理作用
维生素B12可作为蛋氨酸合酶和L-甲基丙二酰−辅酶A突变酶的辅因子。它对于中枢神经系统（CNS）的维护和发育至关重要。维生素B12缺乏会导致巨幼细胞性贫血和神经病变。
维生素B12和叶酸可用于治疗中枢神经系统（CNS）发育、情绪和认知衰退疾病，包括某些痴呆症。
维生素B12调节基因组稳定性。尽管维生素B12 水平升高与肝脏和血液疾病有关；钴胺素缺乏症却与直立性低血压和抑郁症有关。该抗体还可检测辅酶B12和甲基维生素B12，但不与BSA、叶酸和5-甲基四氢叶酸缔合。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
A A M Ermens et al.
Clinical biochemistry, 36(8), 585-590 (2003-11-26)
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a
Christine M Pfeiffer et al.
The Journal of nutrition, 143(6), 957S-965S (2013-04-12)
Biochemical indicators of water-soluble vitamin (WSV) status were measured in a nationally representative sample of the U.S. population in NHANES 2003-2006. To examine whether demographic differentials in nutritional status were related to and confounded by certain variables, we assessed the
M Fenech
Mutation research, 475(1-2), 57-67 (2001-04-11)
Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM)
Henrik Birn et al.
American journal of physiology. Renal physiology, 282(3), F408-F416 (2002-02-08)
Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12). However, the physiological significance of this has not been established, and other TC-B(12) binding proteins have been suggested to mediate renal uptake of this vitamin complex. The
Fumio Watanabe
Experimental biology and medicine (Maywood, N.J.), 232(10), 1266-1274 (2007-10-26)
The usual dietary sources of vitamin B(12) are animal foods, meat, milk, egg, fish, and shellfish. As the intrinsic factor-mediated intestinal absorption system is estimated to be saturated at about 1.5-2.0 microg per meal under physiologic conditions, vitamin B(12) bioavailability
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