推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC18A2(6571)
mouse ... Slc18a2(214084)
rat ... Slc18a2(25549)
一般描述
Vesicular monoamine transporter 2 (VMAT2) , also known as solute carrier family 18 member A2 (SLC18A2), is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding VMAT2 consists of 16 exons and is mapped to human chromosome 10q25.
免疫原
synthetic peptide corresponding an internal sequence of human VMAT2. This sequence is identical in mouse and rat.
应用
Anti-VMAT2 antibody produced in rabbit has also been used in immunofluorescence.
Anti-VMAT2 antibody produced in rabbit has been used in western blot analysis.
生化/生理作用
Vesicular monoamine transporter 2 (VMAT2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. VMAT2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.
外形
solution in phosphate buffered saline, containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Vesicular monoamine transporter, type 2 (VMAT2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas.
Freeby M
Islets, 4, 393-397 (2012)
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L
Neurobiology of Aging, 34, e9-13 (2013)
Norepinephrine transporter expression is inversely associated with glycaemic indices: a pilot study in metabolically diverse persons with overweight and obesity.
Straznicky NE
Obesity science & practice, 2, 13-23 (2016)
Decreased striatal vesicular monoamine transporter 2 (VMAT2) expression in a type 1 diabetic rat model: A longitudinal study using micro-PET/CT
Jiang D, et al.
Nuclear Medicine and Biology, 82, 89-95 (2020)
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Longo F
Acta Neuropathologica Communications, 5, 22-22 (2017)
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