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Merck
CN
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文件

安全信息

V6879

Sigma-Aldrich

[Lys8]-Vasopressin

≥98% (HPLC)

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别名:
Lysine vasopressin, Lyspressin
经验公式（希尔记法）:
C46H65N13O12S2
CAS号:
50-57-7
分子量:
1056.22
EC 号:
200-050-5
MDL编号:
MFCD00133970
UNSPSC代码:
51111800
PubChem化学物质编号:
24900764
NACRES:
NA.32

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

检测方案

≥98% (HPLC)

形式

powder

溶解性

0.1 M acetic acid: 20 mg/mL, clear, colorless

UniProt登记号

P01185

运输

ambient

储存温度

−20°C

SMILES字符串

CC(O)=O.NCCCCC(NC(=O)C1CCCN1C(=O)C2CSSCC(N)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(Cc4ccccc4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O

InChI

1S/C46H65N13O12S2.C2H4O2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34;1-2(3)4/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69);1H3,(H,3,4)

InChI key

NKWAIKZITYLOMT-UHFFFAOYSA-N

基因信息

human ... AVP(551)

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Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 [Disulfide Bridge: 1-6]

应用

[Lys8]-Vasopressin was used as a test compound in quantitative analysis of peptides and proteins by using on-line capillary isoelectric focusing-mass spectrometry.The product was used for studying the coupling of a polymer-based microchip electrophoresis to MALDI-TOF MS by using rotating ball interface.

生化/生理作用

Predominant form of vasopressin present in pigs and marsupials. It has lower vasopressor and antidiuretic activity than Arg8-vasopressin.
[Lys8]-Vasopressin also refers as Lysine vasopressin or Lyspressin is the predominant form of vasopressin present in pigs and marsupials. It antagonizes the amnesia in rats. Lyspressin can also induce resistance to extinction of active avoidance behaviour.

制备说明

2 mg of [Lys8]-Vasopressin dissolves in 0.1 mL, 0.1M HOAc to yield a clear, colorless solution.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

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Vladimír Hrabovský et al.
Wiener klinische Wochenschrift, 124(23-24), 815-821 (2012-11-28)
Hypocholesterolemia is commonly found in critically ill patients; however, the aetiology of this condition remains unclear. Several clinical studies refer to the possible negative impact of haemodilution on cholesterol (CH) metabolism in acute medical conditions. The aim of this study
Gin-Ho Lo et al.
Journal of gastroenterology and hepatology, 28(4), 684-689 (2013-01-03)
Endoscopic therapy combined with vasoconstrictor was generally recommended to treat acute variceal bleeding. However, up to 30% of patients may still encounter treatment failure. This trial was to evaluate the efficacy of combination with endoscopic variceal ligation (EVL) and proton
M Radicioni et al.
Journal of perinatology : official journal of the California Perinatal Association, 32(11), 893-895 (2012-11-07)
Experience with terlipressin (TP) in the neonatal field is scarce. We describe the effects of TP on pulmonary circulation, studied with echocardiography, in an asphyxiated septic cooled infant with pulmonary hypertension (PH) who developed catecholamine-resistant hypotension and exacerbation of PH
D de Wied et al.
British journal of pharmacology, 45(1), 118-122 (1972-05-01)
1. Lysine vasopressin induces resistance to extinction of active avoidance behaviour (De Wied, 1971).2. Digestion of lysine vasopressin with trypsin almost completely destroys the pressor-, antidiuretic-, oxytocic- and corticotrophin-releasing factor activities of lysine vasopressin, but does not materially influence its
Chris Corbett et al.
European journal of gastroenterology & hepatology, 25(3), 344-351 (2013-01-29)
Variceal bleeding has a 6-week mortality of 20%. Recent evidence suggests that early covered transjugular intrahepatic portosystemic stent shunts (TIPSS) can improve outcomes following a variceal bleed in selected patients. We aim to assess the outcomes following the insertion of
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