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Merck
CN
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安全信息

V6130

Sigma-Aldrich

血管活性肠肽人、猪、大鼠

synthetic, ≥95% (HPLC), powder

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别名:
VIP
经验公式（希尔记法）:
C147H238N44O42S
CAS号:
40077-57-4
分子量:
3325.80
MDL编号:
MFCD00167535
UNSPSC代码:
12352200
PubChem化学物质编号:
24900760
NACRES:
NA.32

生物来源

synthetic

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

溶解性

1% acetic acid: soluble, clear, colorless

UniProt登记号

P01282

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc4c[nH]cn4)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI

1S/C147H238N44O42S/c1-18-75(12)115(143(231)182-97(56-72(6)7)131(219)174-94(118(156)206)61-108(153)199)189-140(228)106(68-193)186-135(223)102(63-110(155)201)179-132(220)96(55-71(4)5)176-133(221)98(58-81-37-41-84(196)42-38-81)177-126(214)88(33-23-26-49-149)168-124(212)89(34-24-27-50-150)172-141(229)113(73(8)9)187-119(207)76(13)165-122(210)93(47-53-234-17)171-128(216)92(45-46-107(152)198)170-123(211)87(32-22-25-48-148)167-125(213)90(35-28-51-162-146(157)158)169-130(218)95(54-70(2)3)175-127(215)91(36-29-52-163-147(159)160)173-144(232)116(78(15)194)190-137(225)99(59-82-39-43-85(197)44-40-82)178-134(222)101(62-109(154)200)180-136(224)104(65-112(204)205)184-145(233)117(79(16)195)191-138(226)100(57-80-30-20-19-21-31-80)183-142(230)114(74(10)11)188-120(208)77(14)166-129(217)103(64-111(202)203)181-139(227)105(67-192)185-121(209)86(151)60-83-66-161-69-164-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,192-197H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,201)(H2,156,206)(H,161,164)(H,165,210)(H,166,217)(H,167,213)(H,168,212)(H,169,218)(H,170,211)(H,171,216)(H,172,229)(H,173,232)(H,174,219)(H,175,215)(H,176,221)(H,177,214)(H,178,222)(H,179,220)(H,180,224)(H,181,227)(H,182,231)(H,183,230)(H,184,233)(H,185,209)(H,186,223)(H,187,207)(H,188,208)(H,189,228)(H,190,225)(H,191,226)(H,202,203)(H,204,205)(H4,157,158,162)(H4,159,160,163)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1

InChI key

HEOYHMUESMJFDC-RIWXPGAOSA-N

基因信息

human ... VIP(7432)

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相关类别

Amino Acid Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

一般描述

Vasoactive Intestinal Peptide (VIP) is expressed in airway epithelial cells, secretory glands, immune and inflammatory cells. It functions as a neuroendocrine hormone and putative neurotransmitter. It stimulates neuronal survival and modulates glycogen metabolism. VIP blocks mitogen-activated proliferation of T cells by preventing interleukin-2 production. It promotes electrolyte secretion and provides protection against oxidant injury.

应用

Vasoactive Intestinal Peptide human, porcine, rat has been used to study its ability to stimulate adenosine 3′,5′-cyclic monophosphate (cyclic AMP) formation in the hypothalamus and cerebral cortex of chick and rats.
Vasoactive Intestinal Peptide human, porcine, rat was used to treat human donor corneoscleral explants to maintain corneal endothelial (CE) integrity during eye banking. The product was also used as a test compound for studying its impact on swimbladder blood flow by using saline- or blood-perfused swimbladder preparations of the freshwater European eel Anguilla Anguilla.

生化/生理作用

广泛分布于中枢和外周神经系统的神经肽。本品为血管扩张剂、支气管扩张剂和平滑肌松弛剂。它调节许多免疫系统细胞类型的活性。是胚胎交感神经元的有丝分裂原。其神经保护作用是通过神经胶质细胞释放活性依赖性神经营养因子介导的。
Vasoactive Intestinal Peptide human, porcine, rat (VIP) is a neuropeptide synthesized in the central nervous system that enhances the formation of adenosine 3′,5′-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP modulates the cholinergic as well as serotonergic neurotransmitter systems.

制备说明

Vasoactive Intestinal Peptide human, porcine, rat dissolves in distilled water and1% acetic acid to yield a clear, colorless solution.

其他说明

Lyophilized from 0.1% TFA in H2O

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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Schwerte et al.
The Journal of experimental biology, 202 (Pt 8), 1005-1013 (1999-03-23)
The effects of &bgr;-adrenergic stimulation, vasoactive intestinal polypeptide (VIP), adenosine, the nitric oxide (NO)-releasing agent sodium nitroprusside and of metabolic end-products of gas gland cell metabolism on swimbladder blood flow were investigated using saline- or blood-perfused swimbladder preparations of the
Andrzej Rychlik et al.
Animals : an open access journal from MDPI, 10(10) (2020-10-02)
Canine inflammatory bowel disease (IBD) is a group of enteropathies with nonspecific chronic symptoms and poorly understood etiology. Many aspects connected with IBD are not understood. One of them is the participation of the intestinal nervous system in the development
International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
Harmar AJ, et al.
Pharmacological Reviews, 50(2), 265-270 (1998)
Nobuyuki Hinata et al.
The Journal of urology, 193(3), 1052-1059 (2014-09-23)
We identified the cavernous nerve mesh that exists caudal or posterior to the periprostatic region between the bilateral slings of the levator ani. We also assessed whether nonnerve sparing radical prostatectomy could be modified. Using histological sections from 24 elderly
Vasoactive intestinal peptide
Said SI.
Handbook of Biologically Active Peptides, 1307-1311 (2006)
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