所有图片(1)
About This Item
经验公式（希尔记法）:
C27H34O9
CAS号:
分子量:
502.55
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥85.0% (HPLC)
储存温度
−20°C
SMILES字符串
CC1CCOC(=O)\C=C\C=C\C(=O)OC2CC3OC4C=C(C)CCC4(COC(=O)C1O)C2(C)C35CO5
InChI
1S/C27H34O9/c1-16-8-10-26-14-33-24(31)23(30)17(2)9-11-32-21(28)6-4-5-7-22(29)36-18-13-20(35-19(26)12-16)27(15-34-27)25(18,26)3/h4-7,12,17-20,23,30H,8-11,13-15H2,1-3H3/b6-4+,7-5+
InChI key
NLUGUZJQJYVUHS-YDFGWWAZSA-N
一般描述
Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
应用
Verrucarin A from Myrothecium sp has been used:
- as a translation initiation inhibitor in P. falciparum W2 strain
- as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
- to test its cytotoxicity in renal cell carcinoma cells
生化/生理作用
Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
Verrucarin A is phytotoxic to plantlet cultures and cytotoxic to cultured mammalian cell lines.
其他说明
Macrocyclic trichothecene mycotoxin.
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Chien-Shan Cheng et al.
Cancer cell international, 19, 92-92 (2019-04-24)
In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been studied in vitro, in vivo and clinical studies. This review aims to
Maria C Dzialo et al.
The Journal of biological chemistry, 289(44), 30511-30524 (2014-09-19)
Methylation of various components of the translational machinery has been shown to globally affect protein synthesis. Little is currently known about the role of lysine methylation on elongation factors. Here we show that in Saccharomyces cerevisiae, the product of the
Dorrah Deeb et al.
International journal of oncology, 49(3), 1139-1147 (2016-08-31)
Pancreatic ductal adenocarcinoma (PDA) remains one of the most difficult to treat of all malignancies. Multimodality regimens provide only short-term symptomatic improvement with minor impact on survival, underscoring the urgent need for novel therapeutics and treatment strategies for PDA. Trichothecenes
Charles S Bond et al.
The Journal of cell biology, 186(5), 637-644 (2009-09-02)
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and
Antonio L Amelio et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(51), 20314-20319 (2007-12-14)
Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these pathways as the conduit to the basic transcriptional machinery. Here we present a high-throughput cell-based screening strategy, termed the "coactivator trap,"
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