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安全信息

V4253

Sigma-Aldrich

[β-巯基-β,β-环戊亚甲基丙酰1, O-Et-Tyr2, Val4, Arg8]-加压素

≥97% (HPLC)

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About This Item

经验公式（希尔记法）:
C53H75N13O11S2
CAS号:
77453-01-1
分子量:
1134.37
MDL编号:
MFCD00076752
UNSPSC代码:
51111800
PubChem化学物质编号:
329829049
NACRES:
NA.32
生物来源:
synthetic (organic)
表单:
powder
方案:
≥97% (HPLC)

生物来源

synthetic (organic)

质量水平

200

方案

≥97% (HPLC)

表单

powder

溶解性

water: 1 mg/mL, clear, colorless

运输

ambient

储存温度

−20°C

SMILES字符串

CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC2=O)C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1

InChI

1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,44-/m0/s1

InChI key

SDFJYGJKEXYVCG-ZZTMPEIHSA-N

基因信息

human ... AVPR1A(552) , AVPR2(554) , OXT(5020) , OXTR(5021)
mouse ... AVPR1A(54140) , AVPR2(12000)
rat ... AVPR1A(25107) , AVPR2(25108) , OXT(18429) , OXTR(18430)

Amino Acid Sequence

(1-Mercaptocyclohexyl)acetyl-Tyr(O-Ethyl)-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

应用

[Beta-Mercapto-beta, beta-cyclopentamethylenepropionyl1, O-Et-Tyr2, Val4, Arg8]-Vasopressin is a potent V1a and V2 vasopressin receptor anatgonist, used for examining the impact of vasopressin V1receptor blockade in rats.The product was also be used for visualizing cell surface V1a receptors in rat hepatocytes by using high-affinity fluorescent linear antagonist, Rhm8 -PVA.

生化/生理作用

Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H332

危险分类

Acute Tox. 4 Inhalation

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000267635
SLCQ8849
0000267635
SLCQ5706
031M1823V

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S Ishikawa et al.
Kidney international, 30(1), 49-55 (1986-07-01)
Elevated levels of plasma arginine vasopressin (AVP) have been suggested to impair water excretion in congestive heart failure. In the present study, to determine a role for AVP in the impaired water excretion in rats with the inferior vena cava
S C Mah et al.
Peptides, 9(3), 595-600 (1988-05-01)
The interaction of an antagonist of arginine vasopressin (AVP), d(CH2)5-D-Tyr(Et)VAVP, with renal tubular V2 receptors were studied in medullary membrane preparations from kidneys of Sprague-Dawley and Brattleboro rats. In both rat strains, V2 receptors had comparable KD and Bmax values
M K Sun et al.
European journal of pharmacology, 304(1-3), 63-71 (1996-05-23)
We examined whether vasomotor neurons in the rostroventrolateral reticular nucleus of the medulla oblongata might be responsible for an acute increase in arterial pressure, elicited by application of angiotensin II in the central nervous system, as suggested by others. In
H Tsushima et al.
Japanese journal of pharmacology, 66(2), 241-246 (1994-10-01)
We investigated the effects of angiotensin II (Ang II), microinjected into the supraoptic (SON) and paraventricular (PVN) nuclei of rats, on the urine outflow rate and underlying mechanisms. Ang II produced antidiuretic effects in a dose-dependent manner with ED50 values
M Manning et al.
Journal of peptide science : an official publication of the European Peptide Society, 3(1), 31-46 (1997-01-01)
We report the solid-phase synthesis and some pharmacological properties of 12 position three modified analogues (peptides 1-12) of the potent non-selective antagonist of the antidiuretic (V2-receptor), vasopressor (V1a-receptor) responses to arginine vasopressin (AVP) and of the uterine contracting (OT-receptor) responses
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