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V3639

Sigma-Aldrich

缬氨霉素

Ready Made Solution, ~1 mg/mL in DMSO

别名:

Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

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About This Item

经验公式（希尔记法）:
C54H90N6O18
CAS号:
2001-95-8
分子量:
1111.32
Beilstein:
78657
MDL编号:
MFCD00005114
UNSPSC代码:
51102829
PubChem化学物质编号:
24900743
NACRES:
NA.76

生物来源

Streptomyces sp.

质量水平

200

方案

≥90% (HPLC)

表单

liquid

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)

浓度

~1 mg/mL in DMSO

颜色

colorless

抗生素抗菌谱

Gram-positive bacteria
parasites
viruses

作用机制

cell membrane | interferes

运输

wet ice

储存温度

2-8°C

SMILES字符串

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI key

FCFNRCROJUBPLU-RPUZOQEISA-N

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相关类别

一般描述

化学结构：肽

应用

缬氨霉素是具有钾离子性质的环状十二肽。 它用于研究生物系统中的离子运输。 用于研究其对完整细胞及细菌、酵母菌生长的抑制作用。 用于诱导细胞凋亡。

生化/生理作用

K+选择性离子载体环羧酚酸肽；钾离子载体，其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。
K+选择性离子载体，其可解耦氧化磷酸化作用。
缬氨霉素是一种K+-选择性离子载体环缩肽。 它是一种钾离子载体，其可解偶联氧化磷酸化，诱导鼠胸腺细胞凋亡，抑制NGF诱导的神经元分化，并拮抗ET诱导的血管收缩。 据报道它具有杀虫、杀线虫和抗病毒作用。

其他说明

保存于密闭容器内，置于干燥通风处。吸湿的。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000412211
0000412211
0000410645
0000410645
0000221490

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