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Merck
CN

V3638

Sigma-Aldrich

Vascular Endothelial Growth Factor 164 from rat

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

别名:

VEGF 164, VEGF-164, VEGF164, Vasculotropin

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About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.32

产品名称

Vascular Endothelial Growth Factor 164 from rat, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

生物来源

rat

质量水平

重组

expressed in NSO cells

方案

>95% (SDS-PAGE)

表单

lyophilized powder

效能

1.08 ng/mL ED50

分子量

dimer 50 kDa by SDS-PAGE
monomer 25 kDa by SDS-PAGE

包装

pkg of 10 μg

储存条件

avoid repeated freeze/thaw cycles

杂质

endotoxin, tested

UniProt登记号

储存温度

−20°C

基因信息

应用

Vascular Endothelial Growth Factor 164 (VEGF 164) from rat was used for cardiomyocytes culture and Ca2+ transients′ measurement. It was used as a medium M-199 supplement utilized in in vitro incubation for examining the capability of CTS to limit the impact of biologically relevant molecules, in particular epidermal growth factor (EGF), basic fibroblast growth factor (FGF2), and vascular endothelial growth factor A (VEGFA) in rat epididymis segment 1 and 2.

生化/生理作用

Mitogen for endothelial cells, enhances vascular permeability, activates, and chemoattracts monocytes and is a procoagulant.
Vascular Endothelial Growth Factor 164 also referred to as VEGF 164 or Vasculotropin is a growth factor that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF 164 can enhance collagen and fibronectin expression in mesangial cells which in turn stimulates TGF-β1-induced extracellular matrix. It also plays a pivotal role in progressive glomerular fibrosis.

其他说明

164 amino acid variant of rat VEGF.

外形

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA containing 0.5 mg bovine serum albumin.

分析说明

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jose L Tomsig et al.
Biology of reproduction, 75(4), 598-604 (2006-07-21)
Previous evidence has shown that sperm maturation is the result of successive events that influence sperm cells as they move through different microenvironments from the caput to the cauda epididymis. The physiological basis for the creation and maintenance of specific
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Genes & development, 19(13), 1624-1634 (2005-07-07)
The strength of the heart beat can accommodate in seconds to changes in blood pressure or flow. The mechanism for such homeostatic adaptation is unknown. We sought the cause of poor contractility in the heart of the embryonic zebrafish with
Mujun Sun et al.
Frontiers in molecular neuroscience, 15, 937350-937350 (2022-11-18)
Mild traumatic brain injury (mTBI) is a common and unmet clinical issue, with limited treatments available to improve recovery. The cerebrovascular system is vital to provide oxygen and nutrition to the brain, and a growing body of research indicates that
Lin Wang et al.
The Journal of biological chemistry, 279(32), 33213-33219 (2004-05-15)
Transforming growth factor-beta1 (TGF-beta1) is a potent inducer of extracellular matrix synthesis leading to progressive glomerular fibrosis. The intracellular signaling mechanisms involved in this process remain incompletely understood. The p38 mitogen-activated protein kinase (MAPK) is a major stress signal transducing
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis. VEGF is a promising target for therapeutic intervention in

商品

VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.

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