V2889
Valeryl Salicylate
≥98% (HPLC)
别名:
2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa
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关于此项目
经验公式（希尔记法）:
C12H14O4
化学文摘社编号:
分子量:
222.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Valeryl Salicylate, ≥98% (HPLC)
InChI key
WJHZBTMHUNVIKC-UHFFFAOYSA-N
SMILES string
CCCCC(=O)Oc1ccccc1C(O)=O
InChI
1S/C12H14O4/c1-2-3-8-11(13)16-10-7-5-4-6-9(10)12(14)15/h4-7H,2-3,8H2,1H3,(H,14,15)
assay
≥98% (HPLC)
form
solid
color
white
mp
86-87 °C (lit.)
solubility
DMSO: 24 mL/mL
H2O: insoluble
Quality Level
Biochem/physiol Actions
Selective, irreversible COX-1 inhibitor. The selectivity for COX-1 vs COX-2 shows the IC50 values for ovine COX-1 vs COX-2 of 0.8 μM vs. 15 mM respectively.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Sharath Kandhi et al.
Pulmonary circulation, 9(4), 2045894019895947-2045894019895947 (2020-01-08)
Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by CYP/epoxygenase and metabolized by soluble epoxide hydrolase (sEH). Roles of EETs in hypoxia-induced pulmonary hypertension (HPH) remain elusive. The present study aimed to investigate the underlying mechanisms, by which EETs potentiate
Eduardo Candelario-Jalil et al.
Journal of neuroinflammation, 4, 25-25 (2007-10-12)
Neuroinflammatory responses are triggered by diverse ethiologies and can provide either beneficial or harmful results. Microglial cells are the major cell type involved in neuroinflammation, releasing several mediators, which contribute to the neuronal demise in several diseases including cerebral ischemia
Jing Huang et al.
Pulmonary circulation, 9(1), 2045894019837876-2045894019837876 (2019-02-27)
Caveolin-1 (cav-1) has been shown to play a significant role in the pathogenesis of pulmonary hypertension (PH). In the monocrotaline model of PH, the loss of endothelial cav-1 as well as reciprocal activation of proliferative and anti-apoptotic pathways initiate the
Hui Chen et al.
American journal of physiology. Heart and circulatory physiology, 314(3), H681-H691 (2017-11-12)
Hypertension is associated with endothelial dysfunction, which favors the release of endothelium-derived contracting factors, including vasoconstrictor prostanoids and reactive oxygen species. Peroxisome proliferator-activated receptor-α (PPAR-α) agonists, clinically used as lipid-lowering drugs, possess antioxidant properties and exert beneficial effects in the
Ju-Fang Liu et al.
Molecular cancer, 9, 43-43 (2010-02-25)
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of
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