推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 90 kDa
种属反应性
rat
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
技术
microarray: suitable
western blot: 1:1,000 using whole cell extract of 293T cells expressing rat VR-1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TRPV1(7442)
相关类别
一般描述
Vanilloid Receptor-1 (VR-1) is a cation channel protein that stimulates a burning pain sensation upon binding to capsaicin, a component of ′hot′ chilli peppers. VR-1 is also activated by noxious heat stimuli. Moreover, VR-1 can combine both, heat and chemical stimuli to cause a sensation of pain in vivo.
特异性
Anti-Vanilloid Receptor-1 antibody is specific for vanilloid receptor-1 (90 kDa) in rats. The vanilloid receptor-1 immunizing peptide (rat, amino acids 817-838) specifically inhibits the staining of the vanilloid receptor-1 band in immunoblotting.
免疫原
synthetic peptide corresponding to the C-terminus of rat vanilloid receptor-1 (amino acids 817-838) conjugated to KLH. The sequence is highly conserved in guinea pig (~85% identity) and human (~70% identity) and is not found in rat VRL-1.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Elvira Varela-López et al.
Oxidative medicine and cellular longevity, 2021, 8531975-8531975 (2021-08-17)
The potential transient vanilloid receptor type 1 (TRPV1) plays important functional roles in the vascular system. In the present study, we explored the role of the TRPV1 in the production of nitric oxide (NO), biopterines (BH4 and BH2), cyclic guanosine
M Tominaga et al.
Neuron, 21(3), 531-543 (1998-10-13)
Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of
M J Caterina et al.
Nature, 389(6653), 816-824 (1997-12-31)
Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. We have used an expression cloning strategy based on
Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1).
Claire A Sand et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 63(6), 449-453 (2015-03-27)
Amanda Jabin Fågelskiöld et al.
Islets, 4(1), 56-63 (2012-01-26)
We have studied whether functional TRPV1 channels exist in the INS-1E cells, a cell type used as a model for β-cells, and in primary β-cells from rat and human. The effects of the TRPV1 agonists capsaicin and AM404 on the
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