生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 65 kDa
种属反应性
rat
技术
western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC17A6(57084)
mouse ... Slc17a6(140919)
rat ... Slc17a6(84487)
一般描述
Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.
免疫原
synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.
应用
Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:
- western blot
- immunolabelling.
- immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
生化/生理作用
Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.
Moyer C E, et al.
Schizophrenia Research, 149(1), 127-134 (2013)
Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres.
Virolainen S-M, et al.
Development, 139(20), 3795-3805 (2012)
SLC17: a functionally diverse family of organic anion transporters.
Reimer R J.
Molecular Aspects of Medicine, 350-359, 34(2-343) (2013)
Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.
Dragatsis I, et al.
Neurobiology of Disease, 111, 102-117 (2017)
Yun-Ping Deng et al.
Frontiers in systems neuroscience, 8, 198-198 (2014-11-02)
Motor slowing and forebrain white matter loss have been reported in premanifest Huntington's disease (HD) prior to substantial striatal neuron loss. These findings raise the possibility that early motor defects in HD may be related to loss of excitatory input
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