推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 31 kDa
种属反应性
mouse, rat, human
技术
microarray: suitable
western blot: 1:2,000 using rat liver mitochondria extract or rat liver extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... VDAC1(7416)
mouse ... Vdac1(22333)
rat ... Vdac1(83529)
一般描述
Voltage dependent anion channel 1 (VDAC1) is a highly regulated β-barrel membrane protein, encoded by the gene mapped to human chromosome 5q31.1. The encoded protein is a member of VDAC protein family and is mainly localized in the outer mitochondrial membrane.
免疫原
synthetic peptide located at an internal putative cytoplasmic loop of human VDAC1/Porin (amino acids 152-169) conjugated to KLH. The sequence is identical in bovine and rabbit VDAC1, highly conserved in mouse and rat VDAC1 (single amino acid substitution), and has considerable homology (60-70%) with the human, rat, and mouse VDAC isoforms VDAC2 and VDAC3.
应用
Anti-VDAC/porin antibody produced in rabbit has been used in western blotting.
生化/生理作用
Voltage dependent anion channel 1 (VDAC1) plays an essential role in several cellular processes. It helps in transport of ions and metabolites between the mitochondria and cytosol of the cell. Oligomerization of this protein facilitates discharge of cytochrome c to the cytoplasm, leading to apoptosis. VDAC1 expression is associated with the development of human papillomavirus (HPV)-related cervical cancer. Thus, VDAC1 knock down can be considered as a potent therapeutic strategy for treating HPV-induced cervical disease.
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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