V1255
D -缬氨酸
BioReagent, suitable for cell culture
别名:
D-α-氨基异戊酸, D-2-氨基-3-甲基丁酸
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关于此项目
线性分子式:
(CH3)2CHCH(NH2)CO2H
化学文摘社编号:
分子量:
117.15
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
EC Number:
211-368-9
Beilstein/REAXYS Number:
1721135
MDL number:
产品名称
D -缬氨酸, BioReagent, suitable for cell culture
InChI
1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChI key
KZSNJWFQEVHDMF-SCSAIBSYSA-N
SMILES string
CC(C)[C@@H](N)C(O)=O
biological source
synthetic (organic)
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>295 °C (subl.) (lit.)
shipped in
ambient
storage temp.
room temp
Quality Level
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Application
D-缬氨酸已用作下列培养基的补充剂：
- 杜氏改良Eagle培养基(DMEM)/营养混合物F-12 Ham (F-12)，用于小鼠肾近曲小管上皮细胞(RPTC)培养
- 内皮细胞生长培养基MV2，用于大鼠肺微血管内皮细胞(RLMEC)培养
- DMEM/F-12培养基，用于小鼠气管上皮细胞(MTEC)培养
Biochem/physiol Actions
D-缬氨酸适于半合成兽用抗生素、药物和农药等广泛生产应用。
D-缬氨酸在细胞培养中可用作细胞增殖的选择性抑制剂，主要抑制D-氨基酸氧化酶缺乏细胞。 D-缬氨酸一直以来均被用于抑制成纤维细胞生长，同时允许上皮细胞选择性生长。
General description
L-缬氨酸是一种必需的非极性氨基酸。D-缬氨酸是缬氨酸的非蛋白异构体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
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