一般描述
L-缬氨酸是一种必需的非极性氨基酸。D-缬氨酸是缬氨酸的非蛋白异构体。
应用
D-缬氨酸已用作下列培养基的补充剂：
- 杜氏改良Eagle培养基(DMEM)/营养混合物F-12 Ham (F-12)，用于小鼠肾近曲小管上皮细胞(RPTC)培养
- 内皮细胞生长培养基MV2，用于大鼠肺微血管内皮细胞(RLMEC)培养
- DMEM/F-12培养基，用于小鼠气管上皮细胞(MTEC)培养
生化/生理作用
D-缬氨酸适于半合成兽用抗生素、药物和农药等广泛生产应用。
D-缬氨酸在细胞培养中可用作细胞增殖的选择性抑制剂，主要抑制D-氨基酸氧化酶缺乏细胞。 D-缬氨酸一直以来均被用于抑制成纤维细胞生长，同时允许上皮细胞选择性生长。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
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