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安全信息

V1130

Sigma-Aldrich

万古霉素 盐酸盐 来源于东方链霉菌

BioReagent, suitable for plant cell culture

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About This Item

经验公式（希尔记法）:
C66H75Cl2N9O24 · HCl
CAS号:
1404-93-9
分子量:
1485.71
Beilstein:
3704657
UNSPSC代码:
10171502
NACRES:
NA.72

生物来源

Streptomyces orientalis

质量水平

200

产品线

BioReagent

表单

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

浓度

≥900 μg/mg (as vancomycin base)

技术

cell culture | plant: suitable

颜色

, off-white to brown or White to orange-brown

溶解性

H2O: 50 mg/mL, clear, colorless to dark yellow (and Very Faint Orange to Faint Orange)

抗生素抗菌谱

Gram-positive bacteria

应用

agriculture

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES字符串

Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4

InChI

1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

InChI key

LCTORFDMHNKUSG-XTTLPDOESA-N

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一般描述

Chemical structure: glycopeptide
Vancomycin is a heptapeptide.

应用

Vancomycin hydrochloride from Streptomyces orientalis has been used as:
  • an antibiotic in screening: minimal inhibitory concentrations (MICs) Streptomyces coelicolor
  • in treating Leishmania infected sand flies
  • in combined antibiotic treatment in asthma induced mice

生化/生理作用

作用机制：它会抑制 NAM/NAG-肽的末端 D-丙氨酰-D-丙氨酸部分插入。

抗菌谱：对革兰氏阳性细菌有活性。
Vancomycin is used for treating methicillin-resistant Staphylococcus aureus (MRSA) infections and shunt-associated Staphylococcal ventriculitis. It may lead to hypersensitivity reactions like anaphylaxis and red man syndrome. Vanomycin is also used to treat thrombocytopenia and induces drug reaction with eosinophilia and systemic symptoms (DRESS) on usage.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
0000394529
0000141491
0000319886
0000394529
0000319886

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T Asano et al.
Phytopathology, 89(4), 314-319 (2008-10-24)
ABSTRACT Resting spores of Plasmodiophora brassicae were surface-disinfested by treatment with 2% chloramine-T for 20 min and then with an antibiotic solution (1,000 ppm of colistin sulfate, 1,000 ppm of vancomycin hydrochloride, and 6,000 ppm of cefotaxime sodium) for 1
Red man syndrome
Sivagnanam S and Deleu D
Critical Care, 7(2), 119-119 (2002)
Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma
Adami AJ, et al.
Pediatric Research, 84(3), 426-426 (2018)
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis
Xu L, et al.
BMC Genomics, 15(1), 363-363 (2014)
Jyot D Antani et al.
eLife, 10 (2021-01-26)
The canonical chemotaxis network modulates the bias for a particular direction of rotation in the bacterial flagellar motor to help the cell migrate toward favorable chemical environments. How the chemotaxis network in Helicobacter pylori modulates flagellar functions is unknown, which
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