V108
(±)-去甲基维拉帕米 盐酸盐
≥98% (HPLC)
别名:
N-Nor-(±)-verapamil hydrochloride
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关于此项目
经验公式（希尔记法）:
C26H36N2O4 · HCl
化学文摘社编号:
分子量:
477.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H
SMILES string
CC(C)C(CCCNCCC1=CC=C(OC)C(OC)=C1)(C#N)C2=CC(OC)=C(OC)C=C2.Cl
InChI key
OEAFTRIDBHSJDC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
Quality Level
Biochem/physiol Actions
Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Yong-Ji Piao et al.
Archives of pharmacal research, 31(4), 518-522 (2008-05-02)
The aim of this study was to investigate the effects of hesperidin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of
Young Sun Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(8), 766-774 (2012-02-04)
In this study, the pharmacokinetics of verapamil and its active metabolite norverapamil were evaluated following intravenous and oral administration of 10 mg/kg verapamil to rats with hyperlipidaemia (HL) induced by poloxamer 407 (HL rats). The total area under the plasma
Stereoselective determination of verapamil and norverapamil by capillary electrophoresis
Dethy J M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654(1), 121-127 (1994)
M A Garcia et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 377-382 (1997-06-06)
In this paper we develop an high-performance liquid chromatographic method with ultraviolet detection for the determination of verapamil and its primary metabolite norverapamil in biological samples. Both compounds, as well as the internal standard, imipramine, were extracted from alkalinised blood
Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection
Garcia M A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(2), 377-382 (1997)
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