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Merck
CN

V0882

D-Val-Leu-Lys 4-硝基苯胺 二盐酸盐

plasmin substrate

别名:

D-Val-Leu-Lys-pNA 二盐酸盐, D-缬氨酰-L-亮氨酰-L-赖氨酸 4-硝基苯胺 二盐酸盐

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关于此项目

经验公式（希尔记法）:
C23H38N6O5 · 2HCl
化学文摘社编号:
62354-43-2
分子量:
551.51
NACRES:
NA.32
PubChem Substance ID:
24900701
UNSPSC Code:
12352204
MDL number:
MFCD00077899

主要文件

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产品名称

D-Val-Leu-Lys 4-硝基苯胺 二盐酸盐, plasmin substrate

InChI

1S/C23H38N6O5.2ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);2*1H/t18-,19-,20+;;/m0../s1

SMILES string

Cl.Cl.CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI key

VESQMNNSPPEOSZ-ZLARAOTRSA-N

assay

≥98% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow

storage temp.

−20°C

Quality Level

200

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Application

D-Val-Leu-Lys 4-硝基苯胺二盐酸盐已被用作发色底物，以在酰胺分解活性测定和纤溶酶原活化测定中确定由纤溶酶原形成的纤溶酶。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000492620
0000492620
0000479680
0000479680
0000474461

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M Pantzar et al.
Infection and immunity, 66(10), 4976-4980 (1998-09-24)
The binding of iodine-labelled plasminogen to Helicobacter pylori CCUG 17874 was characterized. Inhibition of the binding was observed after preincubation of H. pylori cells with nonradiolabelled plasminogen, lysine, or the lysine analogue epsilon-aminocaproic acid. Fragments of plasminogen, kringles 1 to
J F Liang et al.
Thrombosis research, 97(5), 349-358 (2000-03-10)
The effects and possible role of heparin on tissue plasminogen activator-mediated plasminogen activation was thoroughly investigated. Direct analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated that heparin increased the conversion of plasminogen to plasmin. Experiments by fluorescence quenching suggested that
M Ieko et al.
Seminars in thrombosis and hemostasis, 26(1), 85-90 (2000-05-11)
Antiphospholipid antibodies (aPLs) are associated with an increased incidence of thrombosis, but the mechanisms responsible for thrombosis are unclear. The present study investigated the effect of both beta2-glycoprotein I (beta2-GPI) and aPLs on the activity of extrinsic fibrinolysis. The remaining
K Kolev et al.
Biochimica et biophysica acta, 1247(2), 239-245 (1995-03-15)
The effect of plasmin substrates D-valyl-L-leucyl-lysine-p-nitroanilide (S-2251) and H-D-norleucyl-hexahydrotyrosyl-lysine-p-nitro-anilide (Spectrozyme-PL) on the rate of activation of native human plasminogen in physiological salt solution is studied. Plasminogen activation by two-chain urokinase-type plasminogen activator (urokinase), two-chain tissue-type plasminogen activator (tc-tPA) or trypsin
S Ueshima et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 7(5), 522-529 (1996-07-01)
Staphylokinase (SAK), produced by Staphylococcus aureus, induces fibrinolytic activity in circulation without systemic fibrinolytic activation. Since the effect of blood vessels on the activity of SAK has not yet been clarified, plasminogen activator (PA) activity of SAK in the presence
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实验方案

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

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