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文件

安全信息

V0627

Sigma-Aldrich

缬氨霉素

≥98% (TLC), ≥90% (HPLC)

别名:

Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

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About This Item

经验公式（希尔记法）:
C54H90N6O18
CAS号:
2001-95-8
分子量:
1111.32
Beilstein:
78657
EC 号:
217-896-6
MDL编号:
MFCD00005114
UNSPSC代码:
12352200
PubChem化学物质编号:
24900697
NACRES:
NA.77

质量水平

300

检测方案

≥90% (HPLC)
≥98% (TLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white

溶解性

DMSO: ≥50 mg/mL
H2O: insoluble

抗生素抗菌谱

Gram-positive bacteria
parasites
viruses

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

InChI

1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1

InChI key

FCFNRCROJUBPLU-RPUZOQEISA-N

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相关类别

一般描述

化学结构：肽
缬氨霉素是一种环肽，含有d-缬氨酸、d-α-羟基缬氨酸、l-缬氨酸和l-乳酸，按环-[(l-Val-d-Hyv-d-Val-l-Lac)3]顺序排列。
Valinomycin, a nonribosomal peptide (NRP), is proposed to have a structure of a 24-membered cyclic peptide cyclo-(d-α-hydroxyisovaleryl-d-valyl-l-lactyl-l-valyl)2. It exhibits antitumor properties and plays a major role as a mitophagy activator. Initially isolated as an antibiotic compound, valinomycin has demonstrated antibacterial activity against Mycobacterium tuberculosis. Moreover, it has been identified as a potent antiviral agent against a wide spectrum of viruses, including human coronavirus, bunyavirus, enterovirus, and flavivirus.

应用

缬氨霉素已用于：
  • 平衡大肠杆菌B23菌株中5（和6-）-羧基荧光素琥珀酰酯（cFSE）的胞内pH和胞外pH
  • 作为离子载体平衡乳酸菌（LAB）菌株的细胞内pH值和细胞外pH值
  • 建立酸碱跃迁和K+-缬氨霉素扩散势形成所需的pH值

生化/生理作用

K+选择性离子载体环羧酚酸肽；钾离子载体，其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。
缬氨霉素通过生物和合成膜选择性地转移碱金属离子。金属离子-肽络合物的形成有助于离子运输。缬氨霉素可与钾、铷和铯（K+、Rb+和Cs+）形成稳定的络合物。

包装

10 MG、25 MG、100 MG、500 MG

其他说明

保存于密闭容器内，置于干燥通风处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H310

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

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