推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 60 kDa
种属反应性
human
技术
microarray: suitable
western blot (chemiluminescent): 1:1,000 using synaptic vesicle (SV) fraction of rat brain.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC17A7(57030)
一般描述
VGLUT1 (vesicular glutamate transporter 1, originally termed BNPI and characterized as a Na+/Pi transporter) is a 60 kDa protein. VGLUT2 is enriched in synaptic vesicles and selective for a distinct class of glutaminergic nerve terminals.
Vesicular glutamate transporter 1 (VGLUT1), also called as solute carrier family 17 member 7 (SLC17A7), is encoded by the gene mapped to human chromosome 19q13, a region associated with schizophrenia. VGLUT1 is specifically expressed in neuronal cells in the brain and at higher levels in neuron-enriched regions such as the amygdala and hippocampus. Glia-enriched areas such as the corpus callosum also show moderate level of expression and substantia nigra, subthalamic nuclei and thalamus show low level expression. VGLUT1 is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.
免疫原
synthetic peptide corresponding to a region near the C-terminus of human VGLUT1 (amino aicds 504-520).
生化/生理作用
Vesicular glutamate transporter 1 (VGLUT1) is associated with neuronal pathways that exhibit activity-dependent potentiation, whereas VGLUT2 is expressed in sensory and autonomic pathways that display high fidelity neurotransmission.
Vesicular glutamate transporter 1 (VGLUT1) plays a vital role as a vesicular glutamate transporter in glutamatergic neurons. VGLUT1 expression in the prefrontal cortex functions as a potential neurochemical marker of dementia in Alzheimer′s disease (AD) and antidepressant activity.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Larissa Moutsimilli et al.
Neuropharmacology, 49(6), 890-900 (2005-08-23)
The two recently characterized vesicular glutamate transporters (VGLUT) presynaptically mark and differentiate two distinct excitatory neuronal populations and thus define a cortical and a subcortical glutamatergic system (VGLUT1 and VGLUT2 positive, respectively). These two systems might be differentially implicated in
L Bai et al.
The Journal of biological chemistry, 276(39), 36764-36769 (2001-07-04)
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Packaging and storage of glutamate into glutamatergic neuronal vesicles requires ATP-dependent vesicular glutamate uptake systems, which utilize the electrochemical proton gradient as a driving force. VGLUT1, the first
Alireza Kashani et al.
Neurobiology of aging, 29(11), 1619-1630 (2007-05-29)
Several lines of evidence suggest that the glutamatergic system is severely impaired in Alzheimer disease (AD). Here, we assessed the status of glutamatergic terminals in AD using the first available specific markers, the vesicular glutamate transporters VGLUT1 and VGLUT2. We
VGLUTs in peripheral neurons and the spinal cord: time for a review
Brumovsky PR
ISRN neurology, 2013 (2013)
Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3.
Y Aihara et al.
Cytogenetics and cell genetics, 92(1-2), 167-169 (2001-04-18)
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