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Merck
CN

UC441

Sigma-Aldrich

6´,-7´-Dihydroxybergamottin

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About This Item

经验公式(希尔记法):
C21H24O6
分子量:
372.41
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77

表单

solid

质量水平

颜色

white to light beige

溶解性

ethanol: soluble

储存温度

2-8°C

SMILES字符串

C\C(CCC(O)C(C)(C)O)=C/COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C21H24O6/c1-13(4-6-18(22)21(2,3)24)8-10-26-20-14-5-7-19(23)27-17(14)12-16-15(20)9-11-25-16/h5,7-9,11-12,18,22,24H,4,6,10H2,1-3H3/b13-8+

InChI key

IXZUPBUEKFXTSD-MDWZMJQESA-N

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应用

6′,7′-dihydroxybergamottin has been used to study its effect on the inhibition of cytochrome P450 (CYP)-mediated triazolam hydroxylation in dog liver microsomes.

生化/生理作用

CYP3A4 inhibitor.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

制备说明

6′,-7′-Dihydroxybergamottin is soluble in ethanol and can be further diluted with water.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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M J Hanley et al.
Journal of veterinary pharmacology and therapeutics, 33(2), 189-195 (2010-05-07)
Coadministration of grapefruit juice (GFJ) has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the intestine and liver. Although GFJ inhibits human cytochrome P450 (CYP) 3A

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