推荐产品
形式
solid
储存温度
2-8°C
SMILES字符串
CN(C)C[C@H]1CCCC[C@]1(O)c2cccc(O)c2
InChI
1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1
InChI key
UWJUQVWARXYRCG-HIFRSBDPSA-N
一般描述
O-去甲基曲马多是一种阿片类药物，同时也是曲马多的活性代谢物。其生产的关键酶是多态性细胞色素P450同工酶2D6（CYP2D6）。
应用
O -去甲基曲马多已用于曲马多代谢物在山羊体内的药代动力学研究 。
O-去甲基曲马多可用作阿片类药物，用于测试其对人类自然杀伤细胞的细胞毒性功能的影响。它也可用作气相色谱-质谱法（GC-MS）中的内标物，用于定量测定人尿液样品中的曲马多衍生物。
生化/生理作用
O-去甲基曲马多对阿片受体具有高亲和力，并导致μ阿片受体的镇痛作用。
曲马多的代谢产物
包装
无底玻璃瓶。内含物装在插入的融合锥内。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Mendel Jansen et al.
Clinical pharmacology in drug development, 7(6), 597-612 (2018-06-06)
Four randomized, double-blind, placebo-controlled, 4-period drug-drug interaction studies were conducted in healthy subjects to evaluate the pharmacokinetic and pharmacodynamic (PD) interactions between mirogabalin and commonly used central nervous system depressants. Mirogabalin or placebo was administered alone or with single-dose lorazepam
Michael K Herbert et al.
BMC pharmacology, 7, 5-5 (2007-03-21)
Inhibition of intestinal peristalsis is a major side effect of opioid analgesics. Although tramadol is an opioid-like analgesic, its effect on gut motility is little known. Therefore, the effect of (+)-tramadol, (-)-tramadol and the major metabolite O-desmethyltramadol on intestinal peristalsis
Joomi Lee et al.
Drug design, development and therapy, 13, 1751-1761 (2019-06-20)
Aim: Tramadol is widely used to treat acute, chronic, and neuropathic pain. Its primary active metabolite, O-desmethyltramadol (M1), is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to M1 mainly by the cytochrome P450 (CYP) 2D6 enzyme
Mi Jin et al.
The Journal of pharmacy and pharmacology, 72(9), 1232-1238 (2020-05-20)
The objective of this study was to investigate the possible interaction of shikonin and β,β-dimethylacrylshikonin (DSK) with tramadol. Human liver microsome (HLM) and rat liver microsome (RLM) incubation experiments were carried out to assess the half-maximal inhibitory concentration (IC50 )
Dermot P Maher et al.
Anesthesia and analgesia, 128(5), 1013-1021 (2019-02-26)
The use of regional and other opioid-sparing forms of anesthesia has been associated with a decrease in the recurrence of certain malignancies. Direct suppression of human natural killer cells by opioids has been postulated to explain this observation. However, the
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