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表单
powder
药品控制
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
white
mp
192-194 °C
储存温度
2-8°C
InChI
1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h9,13-17,21-22H,3-8,10H2,1-2H3/t13-,14+,15+,16-,17+,18+,19+/m1/s1
InChI key
YMCWOAZGWMZGQT-FPNLOETNSA-N
应用
16αHydroxytestosterone has been used as a reference standard for the evaluation of testosterone metabolites using ultra-performance liquid chromatography/tandem mass spectrometric (UPLC/MS/MS) techniques. This product has also been used to analyze the developmental profiles of testosterone hydroxylases in chickens.
生化/生理作用
CYP2C11 (rat) metabolite; androgenic
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
M Paolini et al.
British journal of pharmacology, 122(2), 344-350 (1997-10-06)
1. The sensitivity of the developing embryo to xenobiotics is highly dependent on the expression of metabolizing enzymes including cytochromes P450 (CYP). In the present study, therefore, the ontogeny of the CYP-dependent system in the chick was investigated with testosterone
H B Lim et al.
Biochemistry international, 28(3), 543-550 (1992-11-01)
The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene-
M Numazawa et al.
Analytical biochemistry, 146(1), 75-81 (1985-04-01)
A sensitive nonradiometric assay of aromatization of 16 alpha-hydroxylated androgens, 16 alpha-hydroxy-4-androstene-3,17-dione (16 alpha-OHA), and 16 alpha-hydroxytestosterone (16 alpha-OHT), has been developed using reverse-phase high-performance liquid chromatography with voltametric detector. The estrogens produced by human placental microsomes, estriol (E3) and
T L Klug et al.
Molecular genetics and metabolism, 89(4), 381-389 (2006-09-19)
Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16alpha-hydroxyestrone (16alphaOHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the
K Sugiyama et al.
Drug metabolism and disposition: the biological fate of chemicals, 22(4), 584-591 (1994-07-01)
P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16 alpha-hydroxyandrostenedione. Because Waxman (J. Biol. Chem. 259, 15481-15490) has reported that the enzyme converts androstenedione to 16
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