UC261
(±)-4-Hydroxydebrisoquin sulfate
别名:
(±)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate, (±)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C10H13N3O · 0.5H2SO4
CAS号:
分子量:
240.27
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
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表单
solid
质量水平
颜色
off-white
mp
267 °C
储存温度
2-8°C
SMILES字符串
OS(O)(=O)=O.NC(=N)N1CC(O)c2ccccc2C1.NC(=N)N3CC(O)c4ccccc4C3
InChI
1S/2C10H13N3O.H2O4S/c2*11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13;1-5(2,3)4/h2*1-4,9,14H,5-6H2,(H3,11,12);(H2,1,2,3,4)
InChI key
AETJLQVZNVTWPH-UHFFFAOYSA-N
应用
(±)-4-Hydroxydebrisoquin sulfate can be used for the metabolic studies of debrisoquin.
生化/生理作用
CYP2D6 metabolite of debrisoquin.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Paula Macedo Cerqueira et al.
Journal of clinical pharmacology, 45(12), 1422-1433 (2005-11-18)
The influence of chronic renal failure on the stereoselective metabolism of rac-metoprolol was investigated in 15 hypertensive patients, 7 of them with chronic renal failure and 8 with normal renal function. They were treated with rac-metoprolol (200 mg) for 7
S C Mitchell et al.
Human & experimental toxicology, 13(8), 537-541 (1994-08-01)
Liver transplantation or the surgical construction of portacaval shunts may radically alter an individual's debrisoquine hydroxylation capacity. Good clinical management should encompass a full awareness of such changing needs and problems in patients who undergo hepatic surgery.
K Laine et al.
Clinical pharmacology and therapeutics, 70(4), 327-335 (2001-10-24)
The ultrarapid metabolizer phenotype of the cytochrome P4502D6 (CYP2D6) enzyme has been considered a relevant cause of nonresponse to antidepressant drug therapy. Prescribing high doses of antidepressants to such patients leads to high concentrations of potentially toxic metabolites and an
O O Simooya et al.
British journal of clinical pharmacology, 45(3), 315-317 (2000-07-15)
To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black Zambians. Twenty healthy black male Zambians were phenotyped for CYP2D6 activity by measuring the debrisoquine/4-hydroxydebrisoquine ratio in a 0-8 h urine sample
M Lanz et al.
Electrophoresis, 18(10), 1875-1881 (1998-02-12)
Using capillary zone electrophoresis with a phosphate buffer at pH 2.5 containing 50 mM heptakis-(2,3,6-tri-O-methyl)-beta-CD as chiral selector, the separation of the enantiomers of the main metabolite of debrisoquine (DEB), 4-hydroxydebrisoquine (4-OHDEB), is reported. For extraction of underivatized urinary DEB
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