UC261
(±)-4-Hydroxydebrisoquin sulfate
别名:
(±)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate, (±)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate
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关于此项目
经验公式（希尔记法）:
C10H13N3O · 0.5H2SO4
化学文摘社编号:
分子量:
240.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI
1S/2C10H13N3O.H2O4S/c2*11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13;1-5(2,3)4/h2*1-4,9,14H,5-6H2,(H3,11,12);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.NC(=N)N1CC(O)c2ccccc2C1.NC(=N)N3CC(O)c4ccccc4C3
InChI key
AETJLQVZNVTWPH-UHFFFAOYSA-N
form
solid
color
off-white
mp
267 °C
storage temp.
2-8°C
Quality Level
Application
(±)-4-Hydroxydebrisoquin sulfate can be used for the metabolic studies of debrisoquin.
Biochem/physiol Actions
CYP2D6 metabolite of debrisoquin.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
L Bertilsson et al.
Pharmacogenetics, 3(2), 94-100 (1993-04-01)
Pronounced differences in the CYP2D6 gene between Chinese and Caucasians have previously been described. There was a low frequency of detrimental mutations in the Chinese CYP2D6 gene causing the poor metabolizer (PM) phenotype. In contrast to Caucasians where the Xba
R F Frye et al.
Journal of chromatography. B, Biomedical applications, 677(1), 178-182 (1996-02-23)
A sensitive and specific reversed-phase high-performance liquid chromatographic assay was developed for the determination of debrisoquine and 4-hydroxydebrisoquine in urine. The urine samples were directly injected following an ether clean-up step which eliminated interference. Separation of the analytes was achieved
R Ismail et al.
Journal of clinical pharmacy and therapeutics, 25(5), 379-383 (2000-12-21)
Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of
Determination of oxidation phenotype by measurement of propafenone urinary metabolic ratios.
P Lledó et al.
Human & experimental toxicology, 12(2), 161-163 (1993-03-01)
P M Cerqueira et al.
Journal of chromatography. B, Biomedical sciences and applications, 749(2), 153-161 (2001-01-06)
Debrisoquine (D), an antihypertensive drug metabolized to 4-hydroxydebrisoquine (4-OHD) by CYP2D6, is commonly used as an in vivo probe of CYP2D6 activity and can be used to phenotype individuals as either extensive (EMs) or poor metabolizers (PMs) of such drugs
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