所有图片(1)
About This Item
经验公式（希尔记法）:
C19H16O5
CAS号:
分子量:
324.33
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
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表单
solid
颜色
colorless
mp
183-185 °C
溶解性
DMSO: soluble
methanol: soluble
储存温度
2-8°C
SMILES字符串
CC(=O)C(O)C(c1ccccc1)C2=C(O)c3ccccc3OC2=O
InChI
1S/C19H16O5/c1-11(20)17(21)15(12-7-3-2-4-8-12)16-18(22)13-9-5-6-10-14(13)24-19(16)23/h2-10,15,17,21-22H,1H3
InChI key
BPZSPAZBZFZZBN-UHFFFAOYSA-N
应用
10-Hydroxywarfarin has been used for stereo-specific metabolic studies. 10-Hydroxywarfarin has also been used to study its inhibitory effects on CYP2C9.
生化/生理作用
Major CYP3A4 metabolite of (R)-warfarin.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
制备说明
10-Hydroxywarfarin is soluble in methanol and DMSO.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Eye Dam. 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Kazuki Takeda et al.
Pesticide biochemistry and physiology, 148, 42-49 (2018-06-13)
Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. However
Drew R Jones et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(15-16), 1056-1062 (2011-04-08)
Coumadin (R/S-warfarin) is a commonly prescribed anticoagulant for over ∼20 million Americans. Although highly efficacious, positive clinical outcomes during warfarin therapy depend on maintaining a narrow therapeutic range for the drug. This goal is challenging due to large inter-individual variability
Z Y Zhang et al.
Analytical biochemistry, 298(1), 40-49 (2001-10-25)
A sensitive assay using high-performance liquid chromatography tandem mass spectrometry (MS/MS) has been established for the quantitative analysis of cytochrome P450 form-specific activities using warfarin as a probe substrate. Four metabolites, 6-, 7-, 8-, and 10-hydroxywarfarin, were chromatographically resolved within
Jie Zhang et al.
Journal of chromatography. A, 1082(2), 235-239 (2005-07-23)
The use of capillary electrophoresis (CE) for the determination of cytochrome P450 3A4 (CYP3A4) activity with R-warfarin as a substrate was investigated. CYP3A4 activity was determined by the quantitation of the product, 10-hydroxywarfarin, based on separation by CE. The separation
Kazuki Takeda et al.
Pesticide biochemistry and physiology, 134, 1-7 (2016-12-05)
Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many reports regarding mutations of vitamin K epoxide reductase
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