UC211
7-Hydroxywarfarin
别名:
3-(α-Acetonylbenzyl)-4,7-dihydrocoumarin, 4-7-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
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关于此项目
经验公式（希尔记法）:
C19H16O5
化学文摘社编号:
分子量:
324.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI
1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3
SMILES string
CC(CC(C1=C(O)C(C=CC(O)=C2)=C2OC1=O)C3=CC=CC=C3)=O
InChI key
SKFYEJMLNMTTJA-UHFFFAOYSA-N
form
solid
color
white
mp
220 °C
solubility
DMSO: soluble
storage temp.
2-8°C
Quality Level
Application
7-Hydroxywarfarin can be used for the metabolic assays of (S)-warfarin.
Biochem/physiol Actions
CYP2C9 metabolite of (S)-warfarin.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
7-Hydroxywarfarin is soluble in DMSO.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
D Lang et al.
Journal of chromatography. B, Biomedical applications, 672(2), 305-309 (1995-10-20)
The formation of 7-hydroxywarfarin in incubations of (S)-warfarin with human liver microsomes reflects their cytochrome P-4502C9 activity. This paper describes a rapid high-performance liquid chromatographic method for the determination of 7-hydroxywarfarin with high sensitivity, selectivity, and a simple sample clean-up
Masahiro Utoh et al.
Biochemical pharmacology, 95(2), 110-114 (2015-03-25)
Cynomolgus monkeys are widely used as non-human primate species in preclinical studies, due to their close evolutionary relationship to humans. Monkey cytochrome P450 2C19 (formerly known as P450 2C75), highly homologous to human P450 2C19, has been identified to be
Tae Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2429-2433 (2008-09-12)
Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated whether these mice have a capacity for drug metabolism similar to that of humans by examining hydroxylation of S-warfarin, which is predominantly metabolized
Xiao-Yang Zhou et al.
Frontiers in pharmacology, 12, 619339-619339 (2021-03-02)
Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness. We analyzed the cytochrome P450 2C9 (CYP2C9) and vitamin
Xuemin Jiang et al.
British journal of clinical pharmacology, 57(5), 592-599 (2004-04-20)
M: The aim of this study was to investigate the effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin. This was an open-label, three-way crossover randomized study in 12 healthy male subjects, who received a
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