所有图片(1)
About This Item
经验公式（希尔记法）:
C19H16O5
CAS号:
分子量:
324.33
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
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表单
solid
颜色
off-white
溶解性
DMSO: soluble
methanol: soluble
储存温度
2-8°C
SMILES字符串
CC(=O)CC(c1ccc(O)cc1)C2=C(O)c3ccccc3OC2=O
InChI
1S/C19H16O5/c1-11(20)10-15(12-6-8-13(21)9-7-12)17-18(22)14-4-2-3-5-16(14)24-19(17)23/h2-9,15,21-22H,10H2,1H3
InChI key
RRZWAMPDGRWRPF-UHFFFAOYSA-N
应用
4-Hydroxywarfarin has been used to study its effects on the inhibition of CYP2C9-mediated S-warfarin metabolism.
生化/生理作用
Minor CYP3A4 metabolite od (S)-warfarin.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
制备说明
4-Hydroxywarfarin is soluble in methanol and DMSO.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
J D Rizzo et al.
Journal of pharmaceutical sciences, 78(3), 183-189 (1989-03-01)
Warfarin, an anticoagulant and "metabolic probe" for cytochrome P-450 isozyme multiplicity, is metabolized to 4'-hydroxywarfarin, a principle mammalian metabolite, using the fungus Cunninghamella bainieri (UI-3065). The metabolite was isolated from cell suspension cultures and characterized by analytical (TLC, HPLC, GC-MS)
J S Ngui et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(6), 877-886 (2001-05-17)
It has been demonstrated that the activity of cytochrome P450 (CYP)3A4 in certain cases is stimulated by quinidine (positive heterotropic cooperativity). We report herein that the 4'- and 10-hydroxylation of S- and R-warfarin are enhanced in human liver microsomal incubations
Drew R Jones et al.
Drug metabolism letters, 4(4), 213-219 (2010-07-10)
Effective coumadin (R/S-warfarin) therapy is complicated by inter-individual variability in metabolism. Recent studies have demonstrated that CYP3A isoforms likely contribute to patient responses and clinical outcomes. Despite a significant focus on CYP3A4, little is known about CYP3A5 and CYP3A7 metabolism
Aref Zayed et al.
Acta pharmaceutica (Zagreb, Croatia), 70(3), 343-357 (2020-02-20)
In this study, high-performance liquid chromatography with fluorescence detection (HPLC-FLD) has been used for the first time, for direct determination of warfarin and its major metabolite, 7-hydroxywarfarin, in rat plasma. The simple and sensitive method was developed using Fortis® reversed-phase
So-Young Kim et al.
Drug metabolism letters, 6(3), 157-164 (2013-01-22)
Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharmacogenetic studies report conflicting findings on the clinical relevance of CYP2C19. A resolution to this controversy
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