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表单
solid
质量水平
颜色
off-white
溶解性
DMF: soluble
储存温度
2-8°C
SMILES字符串
CC[C@@]1(NC(=O)NC1=O)c2ccccc2
InChI
1S/C11H12N2O2/c1-2-11(8-6-4-3-5-7-8)9(14)12-10(15)13-11/h3-7H,2H2,1H3,(H2,12,13,14,15)/t11-/m1/s1
InChI key
UDTWZFJEMMUFLC-LLVKDONJSA-N
生化/生理作用
CYP2B6 metabolite of (S)-(+)-mephenytoin; anticonvulsant; hypnotic.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
制备说明
Nirvanol is soluble in DMF.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
P J Wedlund et al.
Journal of chromatography, 307(1), 121-127 (1984-04-13)
A gas chromatographic method was developed for the determination of the R- and S- enantiomers of the anticonvulsant, mephenytoin, and its N-demethylated metabolite, 5-phenyl-5- ethylhydantoin ( PEH ), in plasma and blood. Direct enantiomeric separation of mephenytoin and its internal
I H Hall et al.
Biomedica biochimica acta, 46(7), 623-634 (1987-01-01)
An investigation of the effects of the S-(+) and R-(-) enantiomers of 5-ethyl-5-phenylhydantoin as hypolipidemic agents was undertaken. The serum cholesterol and triglyceride levels were reduced approximately 40% by either oral or i.p. administration at 20 mg/kg.day of either enantiomer.
Genetic polymorphism of mephenytoin metabolism.
T Inaba
Progress in clinical and biological research, 214, 139-156 (1986-01-01)
B A Diwan et al.
Cancer research, 48(9), 2492-2497 (1988-05-01)
Male F344/NCr rats, 6 wk old, were fed 500 ppm of phenobarbital (PB) or equimolar doses of either 5-ethyl-5-phenylhydantoin (EPH) or 5,5-diethylhydantoin (EEH) in diet for 2 wk and hepatic cytochrome P-450-mediated alkoxyresorufin O-dealkylase and aminopyrine N-demethylase activities were determined.
J W Ko et al.
Drug metabolism and disposition: the biological fate of chemicals, 26(8), 775-778 (1998-08-11)
We tested the ability of human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP or P450) isoforms to catalyze the N-demethylation of nirvanol-free (S)-mephenytoin [(S)-MP] in vitro. In mixed HLMs, the kinetics of (S)-MP N-demethylation suggested two contributing activities.
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