UC175
(S)-(+)-美芬妥英
≥98% (HPLC), solid, CYP2B6 & CYP2C19 substrate
别名:
(S)-(+)-5-乙基-3-甲基-5-苯基-2,4-咪唑烷二酮, (S)-(+)-5-乙基-3-甲基-5-苯基海因
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关于此项目
经验公式（希尔记法）:
C12H14N2O2
化学文摘社编号:
分子量:
218.25
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(S)-(+)-美芬妥英, solid, ≥98% (HPLC)
SMILES string
CC[C@]1(NC(=O)N(C)C1=O)c2ccccc2
InChI
1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1
InChI key
GMHKMTDVRCWUDX-LBPRGKRZSA-N
assay
≥98% (HPLC)
form
solid
color
off-white
mp
135-138 °C
solubility
DMSO: soluble
storage temp.
2-8°C
Quality Level
Application
S-美芬妥因已被用作 CYP2C19 底物，用于分析细胞色素 P450 代谢。S-美芬妥因也被用作基于 LC/MS 的相对活性因子（RAF）分析的探针底物。
Biochem/physiol Actions
CYP2B6 & CYP2C19 底物。Methenytoin 异构体。镇惊；抗癫痫。
Features and Benefits
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Preparation Note
（S）-（+）-美芬妥因可溶于 DMSO。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Malaria journal, 11, 259-259 (2012-08-04)
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Stefan J Dekker et al.
British journal of pharmacology, 176(3), 466-477 (2018-11-18)
The aim of this study was to characterize the human cytochrome P450s (CYPs) involved in oxidative bioactivation of flucloxacillin to 5-hydroxymethyl flucloxacillin, a metabolite with high cytotoxicity towards biliary epithelial cells. The CYPs involved in hydroxylation of flucloxacillin were characterized
Bent H Hellum et al.
Basic & clinical pharmacology & toxicology, 105(1), 58-63 (2009-04-18)
The aim of this study was to evaluate in vitro the dose-dependent induction potential of six commonly used trade herbal products on CYP2C19 and CYP2E1 metabolic activities in cultured human hepatocytes. S-mephenytoin and chlorzoxazone were used as specific CYP substrates
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