所有图片(1)
About This Item
经验公式（希尔记法）:
C12H18N2O4S
CAS号:
分子量:
286.35
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
检测方案
≥98% (HPLC)
形式
solid
颜色
white
mp
100-102 °C
溶解性
ethanol: soluble 12 mg/mL
0.1 M NaOH: soluble 4 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
InChI
1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
InChI key
SJRHYONYKZIRPM-UHFFFAOYSA-N
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应用
4-羟基甲苯磺丁脲已用作标准品，用于测定从甲苯磺丁脲到4'-羟基甲苯磺丁脲的真菌生物转化。
包装
无底玻璃瓶。内含物装在插入式熔锥内。
其他说明
甲苯磺丁脲的代谢物；通过 P450 酶的细胞色素 CYP2CIIC8 和 IIC9 亚家族形成。
制备说明
4-羟基甲苯磺丁脲可溶于乙醇（浓度为 12 mg/mL），也可溶于 0.1 MNaOH（浓度为 4 mg/mL）。它不溶于水。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Y K Leung et al.
Journal of biochemical and biophysical methods, 36(2-3), 87-94 (1998-08-26)
A simple HPLC/fluorescence method to detect hydroxytolbutamide (a major metabolite of the anti-diabetic drug tolbutamide) has been developed. The effects of nicotine and some of its metabolites on tolbutamide hydroxylation is described. An extraction procedure with diethyl ether was followed
Ji-Hong Shon et al.
Pharmacogenetics, 12(2), 111-119 (2002-03-05)
Several recent in-vitro data have revealed that CYP2C19, in addition to CYP2C9, is also involved in the 4-methylhydroxylation of tolbutamide. We evaluated the relative contribution of CYP2C9 and CYP2C19 genetic polymorphisms on the disposition of blood glucose lowering response to
Julia Kirchheiner et al.
Pharmacogenetics, 12(2), 101-109 (2002-03-05)
Tolbutamide is known to be metabolized by cytochrome P450 2C9 (CYP2C9), and the effects of the CYP2C9 amino acid polymorphisms *2 (Arg144Cys) and *3 (Ile359Leu) could be important for drug treatment with tolbutamide and for use of tolbutamide as a
D J Back et al.
British journal of pharmacology, 81(3), 557-562 (1984-03-01)
The effects of various drugs on the pharmacokinetics of tolbutamide have been examined in the rat. Phenobarbitone pretreatment caused a significant decrease in half life and area under the curve (AUC) and a significant increase in clearance and volume of
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
J O Miners et al.
Methods in enzymology, 272, 139-145 (1996-01-01)
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