UC126
4-羟基美芬妥英
Cytochrome P450 inhibitor, solid
别名:
(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮
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关于此项目
经验公式（希尔记法）:
C12H14N2O3
化学文摘社编号:
分子量:
234.25
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
4-羟基美芬妥英,
SMILES string
CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
InChI key
OQPLORUDZLXXPD-UHFFFAOYSA-N
InChI
1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
form
solid
color
white
mp
153-154 °C
storage temp.
2-8°C
Quality Level
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General description
美芬妥英的 YP2C19 代谢物。
Application
4-羟基苯乙妥英已被用于开发超高效液相色谱（UPLC）-串联质谱分析（MS/MS），以评估人尿或血浆样品中的细胞色素P450（CYP）探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。
Biochem/physiol Actions
4-羟基苯乙妥英分解代谢显示出了遗传多态性，并是细胞色素P450 2C19（CYP2C19）活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Nicolas A Stewart et al.
The Analyst, 136(3), 605-612 (2010-11-26)
The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test
Tanaka M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)
High-performance liquid chromatographic determination of urinary 4?-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans
Xie HG, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 125-131 (1995)
J K Coller et al.
British journal of clinical pharmacology, 48(2), 158-167 (1999-07-27)
To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various cytochrome P450 isoforms. The kinetics of the formation of 4'-hydroxymephenytoin and cycloguanil in human liver microsomes from 10 liver samples were determined
C Desiderio et al.
Electrophoresis, 15(1), 87-93 (1994-01-01)
Using cyclodextrin micellar electrokinetic capillary chromatography (CD-MECC), baseline separation of mephenytoin, 4-hydroxymephenytoin and 4-hydroxyphenytoin enantiomers in urine was effected with beta-cyclodextrin. After single-dose administration of 100 mg of racemic mephenytoin, the 0-8 h urine was collected, and enzymatically hydrolyzed urine
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