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文件

UC126

4-羟基美芬妥英

Name: 4-羟基美芬妥英
Brand: SIGMA

别名:

(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮

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About This Item

经验公式（希尔记法）:

C₁₂H₁₄N₂O₃

CAS号:

61837-65-8

分子量:

234.25

MDL编号:

MFCD00142316

UNSPSC代码:

12161501

PubChem化学物质编号:

24724640

NACRES:

NA.77

形式

solid

质量水平

200

颜色

white

mp

153-154 °C

储存温度

2-8°C

SMILES字符串

CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2

InChI

1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)

InChI key

OQPLORUDZLXXPD-UHFFFAOYSA-N

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一般描述

美芬妥英的 YP2C19 代谢物。

应用

4-羟基苯乙妥英已被用于开发超高效液相色谱（UPLC）-串联质谱分析（MS/MS），以评估人尿或血浆样品中的细胞色素P450（CYP）探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。

生化/生理作用

4-羟基苯乙妥英分解代谢显示出了遗传多态性，并是细胞色素P450 2C19（CYP2C19）活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test

Tanaka M, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)

A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.

Nicolas A Stewart et al.

The Analyst, 136(3), 605-612 (2010-11-26)

The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible

High-performance liquid chromatographic determination of urinary 4?-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans

Xie HG, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 125-131 (1995)

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.

J K Coller et al.

British journal of clinical pharmacology, 48(2), 158-167 (1999-07-27)

To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various cytochrome P450 isoforms. The kinetics of the formation of 4'-hydroxymephenytoin and cycloguanil in human liver microsomes from 10 liver samples were determined

High-performance liquid chromatographic determination of urinary 4'-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans.

H G Xie et al.

Journal of chromatography. B, Biomedical applications, 668(1), 125-131 (1995-06-09)

The preferential hydroxylation of (S)-mephenytoin to 4'-hydroxymephenytoin (4'-OH-M) displays a genetic polymorphism of drug metabolism in humans. Thus the excreted 4'-OH-M is considered to be an important marker for the hepatic (S)-mephenytoin 4'-hydroxylase. Accordingly, a mixture of urine containing total

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