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生物来源
human
质量水平
重组
expressed in E. coli (histidine-tagged)
方案
≥95% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~20 kDa
技术
ligand binding assay: suitable
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... UBE2C(11065)
一般描述
Manufactured for Sigma by Boston Biochem., Inc.
应用
Ubiquitin-Carrier Protein H10 (UbcH10) human may be used to study the role of ubiquitin-proteasome system in pathogenesis of human diseases.
生化/生理作用
In conjunction with the anaphase-promoting complex, the protein catalyzes the destruction of both cyclin A and cyclin B.
Ubiquitin-Carrier Protein H10 human also referred to as UbcH10 is a recombinant protein that catalyzes the destruction of cyclin A as well as cyclin B along with the anaphase promoting complex and hence plays a pivotal role in controlling the cell exit from mitosis.
外形
Solution in 50 mM HEPES, pH 8.0, 125 mM NaCl, and 1 mM DTT in 10% glycerol.
WGK
WGK 1
法规信息
新产品
F M Townsley et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2362-2367 (1997-03-18)
Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting
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