产品名称
抗UCP-1 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~32 kDa
species reactivity
mouse, human, rat
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using protease-digested sections of mouse brown adipose tissue.
western blot: 1:1,000 using mitochondrial extract of rat brown adipose tissue
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UCP1(7350)
mouse ... Ucp1(22227)
rat ... Ucp1(24860)
General description
解偶联蛋白(UCP1)是一种32 kDa的线粒体内膜蛋白。它作为形成二聚体的质子通道具有活性。它可以结合嘌呤核苷酸，并且能够被脂肪酸激活。
Immunogen
该合成肽与KLH偶联，其对应于具有N末端半胱氨酸的人UCP1序列（氨基酸145-159）。在大鼠和小鼠UCP1中的相应序列是相同的。
Physical form
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
Application
兔抗UCP-1抗体可用于免疫印迹和免疫组化。
Biochem/physiol Actions
UCP-1抗体能够特异性识别人、小鼠和大鼠的UCP-1。免疫肽能够特异性抑制UCP-1条带的染色。被抗体识别的表位能够耐受常规的福尔马林固定和石蜡包埋。
解偶联蛋白(UCP)是氧化磷酸化酶促解偶联剂的转运蛋白。它们能够将由呼吸链泵出的质子送回到线粒体基质中。UCP-1仅在啮齿类动物和新生儿的褐色脂肪组织(BAT)中，其中，它受去甲肾上腺素和甲状腺激素的调节。UCP-1依赖于一种必需的辅因子——CoQ（泛醌）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
此项目有
Anne Rupprecht et al.
PloS one, 9(2), e88474-e88474 (2014-02-14)
Apart from the first family member, uncoupling protein 1 (UCP1), the functions of other UCPs (UCP2-UCP5) are still unknown. In analyzing our own results and those previously published by others, we have assumed that UCP's cellular expression pattern coincides with
Cold exposure partially corrects disturbances in lipid metabolism in a male mouse model of glucocorticoid excess
van den Beukel JC, et al.
Endocrinology, 156(11), 4115-4128 (2015)
Bert Avau et al.
PloS one, 10(12), e0145538-e0145538 (2015-12-23)
Intestinal chemosensory signaling pathways involving the gustatory G-protein, gustducin, and bitter taste receptors (TAS2R) have been implicated in gut hormone release. Alterations in gut hormone profiles may contribute to the success of bariatric surgery. This study investigated the involvement of
Towards a molecular understanding of adaptive thermogenesis
Lowell BB, et al.
Nature, 404(6778), 652-660 (2000)
Maria Chondronikola et al.
Diabetes, 63(12), 4089-4099 (2014-07-25)
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT
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