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Merck
CN

U5625

尿苷-5′-二磷酸葡糖醛酸 铵盐

98-100%, from Saccharomyces cerevisiae, powder

别名:

UDP-GlcA, UDPGA, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid 铵盐, 尿苷-二磷酸-葡萄糖醛酸 铵盐

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关于此项目

经验公式(希尔记法):
C15H22N2O18P2 · xNH3
化学文摘社编号:
分子量:
580.29 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Assay:
98-100%
Biological source:
Saccharomyces cerevisiae, enzyme from bovine liver (catalase), enzyme from rabbit muscle (LDH)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
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产品名称

尿苷-5′-二磷酸葡糖醛酸 铵盐, 98-100%

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

biological source

Saccharomyces cerevisiae, enzyme from bovine liver (catalase), enzyme from rabbit muscle (LDH)

assay

98-100%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

Application

尿苷 5'-二磷酸葡萄糖醛酸铵盐已用于肝 S9 蛋白中 14 C-睾酮的 UDP-葡糖醛酸基转移酶 (UDGPT) 试验的启动。适用于 UDGPT 含量测定。

Biochem/physiol Actions

尿苷 5'-二磷酸葡萄糖醛酸 (UDGPA) 是内质网中胆红素结合的葡萄糖醛酸供体。

General description

尿苷 5′-二磷酸葡萄糖醛酸 (UDPGA) 是辅助因子,由 udp-葡萄糖和烟酰胺腺嘌呤二核苷酸 (NAD +) 在细胞内通过 udp-葡萄糖脱氢酶的催化活性合成。许多肝制备液中 UDPGA 的浓度范围为 0.3-0.5 mM。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

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Molly Lin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(10), 1021-1027 (2017-08-29)
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Wittig J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 237-243 (2001)
Shupeng Yang et al.
Journal of agricultural and food chemistry, 65(33), 7217-7227 (2017-07-25)
After being incubated with animal and human liver microsomes, metabolites of phase I and II were investigated. A comparison was performed by ultrahigh performance liquid chromatography-quadrupole/time-of-flight coupled to mass spectrometry (UHPLC-Q/TOF). Consequently, a total of four phase I metabolites and
Jimmy Flarakos et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(8), 682-696 (2016-08-09)
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Linderoth M, et al.
Ecotoxicology and Environmental Safety, 68(1), 49-56 (2007)

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