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Merck
CN
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文件

U5625

Sigma-Aldrich

尿苷-5′-二磷酸葡糖醛酸 铵盐

98-100%

别名:

UDP-GlcA, UDPGA, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid 铵盐, 尿苷-二磷酸-葡萄糖醛酸 铵盐

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About This Item

经验公式（希尔记法）:
C15H22N2O18P2 · xNH3
CAS号:
43195-60-4
分子量:
580.29 (free acid basis)
UNSPSC代码:
41106305
PubChem化学物质编号:
24900657
NACRES:
NA.51

生物来源

Saccharomyces cerevisiae
enzyme from bovine liver (catalase)
enzyme from rabbit muscle (LDH)

质量水平

200

检测方案

98-100%

形式

powder

储存温度

−20°C

SMILES字符串

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

相关类别

一般描述

尿苷 5′-二磷酸葡萄糖醛酸 (UDPGA) 是辅助因子，由 udp-葡萄糖和烟酰胺腺嘌呤二核苷酸 (NAD +) 在细胞内通过 udp-葡萄糖脱氢酶的催化活性合成。许多肝制备液中 UDPGA 的浓度范围为 0.3-0.5 mM。

应用

尿苷 5'-二磷酸葡萄糖醛酸铵盐已用于肝 S9 蛋白中 14 C-睾酮的 UDP-葡糖醛酸基转移酶 (UDGPT) 试验的启动。适用于 UDGPT 含量测定。

生化/生理作用

尿苷 5'-二磷酸葡萄糖醛酸 (UDGPA) 是内质网中胆红素结合的葡萄糖醛酸供体。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Molly Lin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(10), 1021-1027 (2017-08-29)
1. Glucuronidation of amines has been shown to exhibit large species differences, where the activity is typically more pronounced in human than in many preclinical species such as rat, mouse, dog and monkey. The purpose of this work was to
Justine Badée et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(2), 124-134 (2018-11-28)
UDP-glucuronosyltransferase (UGT)-mediated metabolism is possibly the most important conjugation reaction for marketed drugs. However, there are currently no generally accepted standard incubation conditions for UGT microsomal assays, and substantial differences in experimental design and methodology between laboratories hinder cross-study comparison
Seasonal testosterone UDP-glucuronosyltransferase activity and biliary steroids in Eurasian perch: Response to leachate exposure
Linderoth M, et al.
Ecotoxicology and Environmental Safety, 68(1), 49-56 (2007)
Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography-tandem mass spectrometry
Wittig J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 237-243 (2001)
Jimmy Flarakos et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(8), 682-696 (2016-08-09)
1. Absorption, distribution, metabolism, transport and elimination properties of omadacycline, an aminomethylcycline antibiotic, were investigated in vitro and in a study in healthy male subjects. 2. Omadacycline was metabolically stable in human liver microsomes and hepatocytes and did not inhibit or induce
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