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生物来源
synthetic (organic)
质量水平
检测方案
≥98% (HPLC)
形式
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-CCXZUQQUSA-N
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一般描述
阿糖尿苷(1-β-d-arabinofuranosyluracil, Ara-U)是阿糖胞苷 (1-β-d-arabinofuranosylcytosin, Ara-C) 的解毒产物或代谢产物。阿糖尿苷(Uracil 1-β-D-arabinofuranoside）是一种名为阿糖胞苷 (CYT) 的细胞生长抑制剂的人体代谢物。
应用
阿糖尿苷(Uracil 1-β-D-arabinofuranoside）可用作通过亲水相互作用色谱/串联质谱法分析医院废水细胞抑制剂和代谢物含量的标准化合物，检验分析实验的可行性和局限性。它还可用作化学分析标准品，研究细胞毒性抗肿瘤药物的生态毒性和遗传毒性，如阿糖胞苷 (CYT) 及其代谢物（如阿糖尿苷(uracil-1-β-d-arabinofuranoside, AraU)）。
生化/生理作用
17 μM浓度的阿糖尿苷(1-β-D-Arabinofuranosyluracil, ara-U)能够抑制 L5178Y 小鼠淋巴瘤细胞增殖。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Radka Zounkova et al.
Chemosphere, 81(2), 253-260 (2010-07-14)
In spite of growing scientific concern about pharmaceuticals in the environment, there is still a lack of information especially with regard to their metabolites. The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine
Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells.
W E Müller et al.
Cancer research, 39(3), 1102-1107 (1979-03-01)
Kai Chen et al.
Nuclear medicine and biology, 39(7), 1019-1025 (2012-04-17)
[(18)F]-FMAU is a PET tracer being evaluated for imaging cell proliferation. Current multi-step procedures of [(18)F]-FMAU synthesis are time-consuming, resulting in low radiochemical yield and inconvenient applications for the clinic. We have previously reported the use of Friedel-Crafts catalysts for
Richard Wiegand et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 891-892, 64-70 (2012-03-14)
A liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) assay was developed and validated for simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and its active metabolite 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma. FAU and FMAU were extracted from plasma samples using
Radka Zounkova et al.
Chemosphere, 81(2), 253-260 (2010-07-14)
In spite of growing scientific concern about pharmaceuticals in the environment, there is still a lack of information especially with regard to their metabolites. The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine
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