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Merck
CN

U5127

熊去氧胆酸

≥99%

别名:

3α,7β-二羟基-5β-胆酸-24-羧酸, 5β-胆酸-24-羧酸-3α,7β-二醇, 7β-羟基石胆酸, UDCS

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关于此项目

经验公式（希尔记法）:
C24H40O4
化学文摘社编号:
128-13-2
分子量:
392.57
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24900651
EC Number:
204-879-3
Beilstein/REAXYS Number:
3219888
MDL number:
MFCD00003680

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产品名称

熊去氧胆酸, ≥99%

assay

≥99%

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1

InChI key

RUDATBOHQWOJDD-UZVSRGJWSA-N

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

description

anionic detergent

form

powder

mol wt

392.57 g/mol

mp

203-204 °C (lit.)

Quality Level

200

Gene Information

human ... NR1H4(9971)

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相关类别

Application

熊去氧胆酸（UDCS）是一种细胞保护剂，广泛用于缓解肝脏和胆道疾病。 熊去氧胆酸可用于研究其特定活性，包括减少胆固醇吸收，溶解胆固醇胆结石，以及抑制免疫反应。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000515736
0000515736
0000519362
0000519363
0000519363

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Ruchika Sharma et al.
Journal of medicinal chemistry, 54(1), 122-130 (2010-12-17)
Ursodeoxycholic acid (UDCA) is used for the treatment of hepatic inflammatory diseases. Recent studies have shown that UDCA's biological effects are partly glucocorticoid receptor (GR) mediated. UDCA derivatives were synthesized and screened for ability to induce GR translocation in a
Wei Zhou et al.
Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)
Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the
Yuan Chen et al.
Molecular endocrinology (Baltimore, Md.), 29(4), 613-626 (2015-02-13)
Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor
Raoul Poupon
Clinics and research in hepatology and gastroenterology, 36 Suppl 1, S3-12 (2012-11-13)
Chronic cholestasis and liver inflammation are the two main pathophysiological components of the two major classes of disease - primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) - leading to bile duct destruction and ultimately to cirrhosis and liver
Yan Gong et al.
The American journal of gastroenterology, 102(8), 1799-1807 (2007-04-27)
Ursodeoxycholic acid (UDCA) is used for primary biliary cirrhosis (PBC), but the beneficial effects remain controversial. We performed an updated systematic review to evaluate the benefits and harms of UDCA in patients with PBC. We included randomized clinical trials evaluating
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