推荐产品
生物来源
human
质量水平
检测方案
≥97% (HPLC)
形式
solid
技术
ligand binding assay: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... UCN3(114131)
Amino Acid Sequence
Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2
应用
Urocortin III human can be used as a test compound for studying the impacts of melanocortin agonist on in vitro α-subunit secretion.
生化/生理作用
Urocortin III belongs to corticotropin-releasing hormone family with high affinity for the type 2 corticotropin-releasing factor (CRFR2) receptor. It stimulates insulin and glucagon secretion.Urocortin III also possesses cardioprotective property and has minimal impact on the hypothalamic stress axis. It is, therefore, utilized for treating ischemic heart disease.
Selective ligand with high affinity for CRF2 Receptors
其他说明
Lyophilized from 0.1% TFA in H2O
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Bhawanjit K Brar et al.
Endocrinology, 145(1), 24-35 (2003-09-13)
Corticotropin-releasing factor (CRF) receptor type 2beta (CRFR2beta) is expressed in the heart. Urocortin (Ucn)-I activation of CRFR2beta is cardioprotective against ischemic reperfusion (I/R) injury by stimulation of the ERKs1/2 p42, 44. However, by binding CRF receptor type 1, Ucn-I can
Chien Li et al.
Endocrinology, 144(7), 3216-3224 (2003-06-18)
Urocortin (Ucn) III, or stresscopin, is a high affinity ligand for the type 2 corticotropin-releasing factor (CRFR2) receptor recently identified in rodents and human. Ucn III was initially identified as a neuropeptide expressed in discrete areas in the brain. In
Bert De Groef et al.
Endocrinology, 144(12), 5537-5544 (2003-09-13)
CRH is known as the main stimulator of ACTH release. In representatives of all nonmammalian vertebrates, CRH has also been shown to induce TSH secretion, acting directly at the level of the pituitary. We have investigated which cell types and
Hock-Kean Liew et al.
Neuropeptides, 52, 89-96 (2015-06-10)
Urocortin exerts neuroprotective effects in intracerebral hemorrhage (ICH) of rats. For pre-clinical trial, we intended to study the neuroprotective efficacy of human UCN (hUCN)-1, -2 and -3 in treating ICH rats. ICH was induced by infusing bacterial collagenase VII (0.23
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