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重组
expressed in E. coli
质量水平
形式
lyophilized powder
比活
≥2 units/mg solid
分子量
35 kDa by SDS-PAGE
储存温度
−20°C
InChI
1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3
InChI key
VPXDHZMLJOJKOX-UHFFFAOYSA-N
一般描述
尿酸是一种同源四聚体蛋白，其活性位点位于头尾单体-二聚体界面。
尿酸缺乏小鼠会发展为尿酸肾病和尿崩症，这可以通过重组尿酸酶治疗来缓解。
应用
念珠菌属的尿囊已用于：
- 消除血浆样品中的尿酸盐，并评估尿酸盐对血浆总抗氧化能力的贡献
- 腹腔注射小鼠，以研究尿酸在纤维蛋白细胞外陷阱（ET）形成中的作用
- 在铁还原/抗氧化能力（FRAP）测定中消除尿酸，以测量人血浆样品的总抗氧化能力；基于尿酸酶的生物传感器
生化/生理作用
尿酸参与嘌呤分解代谢。它催化高度不溶性尿酸转化为 5-羟基异尿酸盐。尿酸的积累会导致肝脏/肾脏损伤或慢性引起痛风。在小鼠中，编码尿酸酶的基因突变会导致尿酸突然升高。缺乏该基因的小鼠会出现高尿酸血症、高尿酸症和尿酸结晶性梗阻性肾病。
单位定义
在 25°C、pH 8.5 的条件下，1 个单位每分钟将把 1.0 μmol 尿酸氧化成尿囊素。
外形
粉末；含柠檬酸盐和蔗糖
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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