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重组
expressed in E. coli
质量水平
表单
lyophilized powder
比活
≥2 units/mg solid
分子量
35 kDa by SDS-PAGE
储存温度
−20°C
SMILES字符串
[P](=O)([O-])(OC3C(OC(C3O)N4C=CC(=O)NC4=O)CO)OCC1OC(C(C1O)O)N2C=CC(=O)NC2=O.[N+H4]
InChI
1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3
InChI key
VPXDHZMLJOJKOX-UHFFFAOYSA-N
一般描述
尿酸是一种同源四聚体蛋白，其活性位点位于头尾单体-二聚体界面。
尿酸缺乏小鼠会发展为尿酸肾病和尿崩症，这可以通过重组尿酸酶治疗来缓解。
应用
念珠菌属的尿囊已用于：
- 消除血浆样品中的尿酸盐，并评估尿酸盐对血浆总抗氧化能力的贡献
- 腹腔注射小鼠，以研究尿酸在纤维蛋白细胞外陷阱（ET）形成中的作用
- 在铁还原/抗氧化能力（FRAP）测定中消除尿酸，以测量人血浆样品的总抗氧化能力；基于尿酸酶的生物传感器
生化/生理作用
尿酸参与嘌呤分解代谢。它催化高度不溶性尿酸转化为 5-羟基异尿酸盐。尿酸的积累会导致肝脏/肾脏损伤或慢性引起痛风。在小鼠中，编码尿酸酶的基因突变会导致尿酸突然升高。缺乏该基因的小鼠会出现高尿酸血症、高尿酸症和尿酸结晶性梗阻性肾病。
单位定义
在 25°C、pH 8.5 的条件下，1 个单位每分钟将把 1.0 μmol 尿酸氧化成尿囊素。
外形
粉末；含柠檬酸盐和蔗糖
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Darko Modun et al.
Atherosclerosis, 197(1), 250-256 (2007-05-15)
By using red wine, dealcoholized red wine, polyphenols-stripped red wine, ethanol-water solution and water, the role of wine polyphenols and induction of plasma urate elevation on plasma antioxidant capacity was examined in humans (n=9 per beverage). Healthy males randomly consumed
Benoit Pugin et al.
Frontiers in microbiology, 13, 853735-853735 (2022-05-03)
Uricase catalyzes the conversion of uric acid into allantoin with concomitant reduction of molecular oxygen to hydrogen peroxide. In humans, uricase is not functional, thereby predisposing individuals to hyperuricemia, a metabolic disturbance associated with gout, chronic kidney disorders, and cardiovascular
Darko Duplancic et al.
Molecules (Basel, Switzerland), 16(8), 7058-7068 (2011-08-19)
Determination of the relative contribution of uric acid level increases to the total measured antioxidative activity could be very useful for testing antioxidative products and their effect on human health. The aim of this report is to present a simple
Rocco Cancelliere et al.
Biosensors, 12(1) (2022-01-21)
The use of carbon nanomaterials (CNMs) in sensors and biosensor realization is one of the hottest topics today in analytical chemistry. In this work, a comparative in-depth study, exploiting different nanomaterial (MWNT-CO2H, -NH2, -OH and GNP) modified screen-printed electrodes (SPEs)
Ze Li et al.
Molecular biology and evolution, 39(1) (2021-11-01)
The role of uric acid during primate evolution has remained elusive ever since it was discovered over 100 years ago that humans have unusually high levels of the small molecule in our serum. It has been difficult to generate a
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